B cell responses: cell interaction dynamics and decisions
JG Cyster, CDC Allen - Cell, 2019 - cell.com
B cells and the antibodies they produce have a deeply penetrating influence on human
physiology. Here, we review current understanding of how B cell responses are initiated; the …
physiology. Here, we review current understanding of how B cell responses are initiated; the …
[HTML][HTML] Mechanisms of central tolerance for B cells
D Nemazee - Nature Reviews Immunology, 2017 - nature.com
Immune tolerance hinders the potentially destructive responses of lymphocytes to host
tissues. Tolerance is regulated at the stage of immature B cell development (central …
tissues. Tolerance is regulated at the stage of immature B cell development (central …
Impact of retinoic acid on immune cells and inflammatory diseases
LM Oliveira, FME Teixeira… - Mediators of inflammation, 2018 - Wiley Online Library
Vitamin A metabolite retinoic acid (RA) plays important roles in cell growth, differentiation,
organogenesis, and reproduction and a key role in mucosal immune responses. RA …
organogenesis, and reproduction and a key role in mucosal immune responses. RA …
Sequential immunization elicits broadly neutralizing anti-HIV-1 antibodies in Ig knockin mice
A vaccine that elicits broadly neutralizing antibodies (bNAbs) against HIV-1 is likely to be
protective, but this has not been achieved. To explore immunization regimens that might …
protective, but this has not been achieved. To explore immunization regimens that might …
The origins, function, and regulation of T follicular helper cells
CS Ma, EK Deenick, M Batten… - Journal of Experimental …, 2012 - rupress.org
The generation of high-affinity antibodies (Abs) plays a critical role in the neutralization and
clearance of pathogens and subsequent host survival after natural infection with a variety of …
clearance of pathogens and subsequent host survival after natural infection with a variety of …
The good, the bad and the ugly — TFH cells in human health and disease
Antibody production is an important feature of the vertebrate immune system. Antibodies
neutralize and clear pathogens, thereby protecting against infectious diseases. Such …
neutralize and clear pathogens, thereby protecting against infectious diseases. Such …
[HTML][HTML] Transcriptional regulation of germinal center B and plasma cell fates by dynamical control of IRF4
K Ochiai, M Maienschein-Cline, G Simonetti, J Chen… - Immunity, 2013 - cell.com
The transcription factor IRF4 regulates immunoglobulin class switch recombination and
plasma cell differentiation. Its differing concentrations appear to regulate mutually …
plasma cell differentiation. Its differing concentrations appear to regulate mutually …
Persistent antigen and germinal center B cells sustain T follicular helper cell responses and phenotype
T follicular helper (Tfh) cells provide help to B cells and are crucial for establishment of
germinal center (GC) reactions, including production of high-affinity antibodies and …
germinal center (GC) reactions, including production of high-affinity antibodies and …
Immunoglobulin class-switch DNA recombination: induction, targeting and beyond
Class-switch DNA recombination (CSR) of the immunoglobulin heavy chain (IGH) locus is
central to the maturation of the antibody response and crucially requires the cytidine …
central to the maturation of the antibody response and crucially requires the cytidine …
Interleukin-2 inhibits germinal center formation by limiting T follicular helper cell differentiation
A Ballesteros-Tato, B León, BA Graf, A Moquin… - Immunity, 2012 - cell.com
T follicular helper (Tfh) cells promote T cell-dependent humoral immune responses by
providing T cell help to B cells and by promoting germinal center (GC) formation and long …
providing T cell help to B cells and by promoting germinal center (GC) formation and long …