Metformin, a US Food and Drug Administration-approved “star” drug used for diabetes
mellitus type 2, has become a topic of increasing interest to researchers due to its anti …

Cancer is an uncontrolled division of cells that has been attributed to various factors due to
the advancement in cell biology and widespread genomic studies. Traditional chemotherapy …

Clonal myeloproliferation and development of bone marrow (BM) fibrosis are the major
pathogenetic events in myelofibrosis (MF). The identification of novel antifibrotic strategies is …

Discovery and development of novel anti-cancer drugs are expensive and time consuming.
Systems biology approaches have revealed that a drug being developed for a non-cancer …

Recent data indicate that IGF1R/IRS signaling is a potential therapeutic target in BCR-ABL1-
negative myeloproliferative neoplasms (MPN); in this pathway, IRS2 is involved in the …

Objective To identify the association between the phosphorylated Janus kinase
2/phosphorylated signal transducer and activator of transcription (p-JAK2/p-STAT3) …

Introduction The third‐generation epidermal growth factor receptor (EGFR) inhibitor
osimertinib is a promising therapeutic option for patients with advanced non‐small‐cell lung …

Myeloproliferative neoplasms (MPNs) are unique hematopoietic stem cell disorders sharing
mutations that constitutively activate the signal-transduction pathways involved in …

Objective Oral tyrosine kinase inhibitors (TKIs) are first line therapy for chronic myeloid
leukemia (CML). A complete cytogenetic response (CCyR) correlates with increased overall …

Fibrosis is the tissue scarring characterized by excess deposition of extracellular matrix
(ECM) proteins, mainly collagens. A fibrotic response can take place in any tissue of the …