There is an unmet need for therapies that can restore bone strength and reduce fracture risk
among patients at high risk of osteoporotic fracture. To address this need, bone-forming …

Osteoporosis is characterized by reduced bone mass and disruption of bone architecture,
resulting in increased risk of fragility fractures and significant long-term disability. Although …

Sclerostin, a protein secreted from osteocytes, negatively regulates the WNT signaling
pathway by binding to the LRP5/6 co-receptors and further inhibits bone formation and …

Osteocyte produced fibroblast growth factor 23 (FGF23) is the key regulator of serum
phosphate (Pi) homeostasis. The interplay between parathyroid hormone (PTH), FGF23 and …

Type 2 diabetes (T2D) is on the rise worldwide and is associated with various complications
in the oral cavity. Using an adult-onset diabetes preclinical model, we demonstrated …

ABSTRACT X‐linked hypophosphatemia (XLH), caused by a loss‐of‐function mutation in
the phosphate regulating gene with homology to endopeptidase located on the X …

Periodontitis is a progressive disease that ultimately leads to bone and tooth loss. A major
consequence of periodontal disease is the inability to regain lost bone in the periodontium …

Vascular calcification and bone fragility are common and interrelated health problems that
affect chronic kidney disease (CKD) patients. Bone fragility, which leads to higher risk of …

X-linked hypophosphatemia (XLH) is caused by a loss-of-function mutation in the phosphate
regulating gene with homology to endopeptidase located on the X chromosome (PHEX) …

Pediatric renal osteodystrophy is characterized by skeletal mineralization defects, but the
role of osteoblast and osteocyte maturation in the pathogenesis of these defects is unknown …