This review delves into the rapidly evolving landscape of liquid biopsy technologies based
on cell-free DNA (cfDNA) and cell-free RNA (cfRNA) and their increasingly prominent role in …

The myeloid neoplasms encompass acute myeloid leukemia, myelodysplastic syndromes
and myeloproliferative neoplasms. Most cases arise from the shared ancestor of clonal …

Clonal hematopoiesis (CH) is described as the outsized contribution of expanded clones of
hematopoietic stem and progenitor cells (HSPCs) to blood cell production. The prevalence …

Age is a predominant risk factor for acute kidney injury (AKI), yet the biological mechanisms
underlying this risk are largely unknown. Clonal hematopoiesis of indeterminate potential …

Canakinumab, a monoclonal antibody targeting proinflammatory cytokine interleukin-1β (IL-
1β), improved hemoglobin levels while preventing recurrent cardiovascular events in the …

Background Historically, survivors of common lymphoid neoplasms (LNs) had increased
risks for therapy-related myelodysplastic syndrome/acute myeloid leukemia (tMDS/AML) …

Abstract Background and Aims Clonal haematopoiesis of indeterminate potential (CHIP), the
age-related expansion of blood cells with preleukemic mutations, is associated with …

Genetic testing has been applied for decades in clinical routine diagnostics of hematological
malignancies to improve disease (sub) classification, prognostication, patient management …

Clonal hematopoiesis (CH) represents the clonal expansion of hematopoietic stem cells and
their progeny driven by somatic mutations. Accurate risk assessment of CH is critical for …

Telomeres protect chromosome ends from damage and their length is linked with human
disease and aging. We developed a joint telomere length metric, combining quantitative …