Carboxylesterases are a multigene family of mammalian enzymes widely distributed
throughout the body that catalyze the hydrolysis of esters, amides, thioesters, and …

A number of anatomical and physiological factors determine the pharmacokinetic profile of a
drug. Differences in physiology in paediatric populations compared with adults can influence …

Following a request from the European Commission to EFSA, the EFSA Scientific Committee
(SC) prepared a guidance for the risk assessment of substances present in food intended for …

Many drugs prescribed to children are drug transporter substrates. Drug transporters are
membrane-bound proteins that mediate the cellular uptake or efflux of drugs and are …

The complex process of oral drug absorption is influenced by a host of drug and formulation
properties as well as their interaction with the gastrointestinal environment in terms of drug …

Effective and safe drug administration in neonates should be based on integrated
knowledge on the evolving physiological characteristics of the infant who will receive the …

Tremendous efforts have been directed to investigate the ontogeny of drug transporters in
fetuses, neonates, infants, and children based on their importance for understanding drug …

Personalized medicine aims to determine the most adequate treatment and dose regimen to
obtain the maximum efficacy and minimum side effect by taking into account patients' …

Sepsis remains a major cause of mortality and morbidity in neonates, and, as a
consequence, antibiotics are the most frequently prescribed drugs in this vulnerable patient …

Although both POPPK and physiologically based pharmacokinetic (PBPK) models can
account for age and other covariates within a paediatric population, they generally do not …