C–H activation

T Rogge, N Kaplaneris, N Chatani, J Kim… - Nature Reviews …, 2021 - nature.com
Transition metal-catalysed C–H activation has emerged as an increasingly powerful platform
for molecular syntheses, enabling applications to natural product syntheses, late-stage …

Transition-metal catalyzed C–H activation as a means of synthesizing complex natural products

SK Sinha, P Ghosh, S Jain, S Maiti… - Chemical Society …, 2023 - pubs.rsc.org
Over the past few decades, the advent of C–H activation has led to a rethink among
chemists about the synthetic strategies employed for multi-step transformations. Indeed …

Recent applications of C–H functionalization in complex natural product synthesis

DJ Abrams, PA Provencher, EJ Sorensen - Chemical Society Reviews, 2018 - pubs.rsc.org
In this review, recent examples featuring C–H functionalization in the synthesis of complex
natural products are discussed. A focus is given to the way in which C–H functionalization …

The medicinal chemist's toolbox for late stage functionalization of drug-like molecules

T Cernak, KD Dykstra, S Tyagarajan… - Chemical Society …, 2016 - pubs.rsc.org
The advent of modern C–H functionalization chemistries has enabled medicinal chemists to
consider a synthetic strategy, late stage functionalization (LSF), which utilizes the C–H …

Strategic application of C–H oxidation in natural product total synthesis

I Bakanas, RF Lusi, S Wiesler… - Nature Reviews …, 2023 - nature.com
The oxidation of unactivated C–H bonds has emerged as an effective tactic in natural
product synthesis and has altered how chemists approach the synthesis of complex …

Navigating the chiral pool in the total synthesis of complex terpene natural products

ZG Brill, ML Condakes, CP Ting, TJ Maimone - Chemical reviews, 2017 - ACS Publications
The pool of abundant chiral terpene building blocks (ie,“chiral pool terpenes”) has long
served as a starting point for the chemical synthesis of complex natural products, including …

Collective approach to advancing C–H functionalization

HML Davies, D Morton - ACS Central Science, 2017 - ACS Publications
C–H functionalization is a very active research field that has attracted the interest of
scientists from many disciplines. This Outlook describes the collaborative efforts within the …

Strategy evolution in a skeletal remodeling and C–H functionalization-based synthesis of the longiborneol sesquiterpenoids

RF Lusi, G Sennari, R Sarpong - Journal of the American …, 2022 - ACS Publications
Detailed herein are our synthesis studies of longiborneol and related natural products. Our
overarching goals of utilizing a “camphor first” strategy enabled by skeletal remodeling of …

Natural product synthesis by C− H activation

SK Sinha, G Zanoni, D Maiti - Asian Journal of Organic …, 2018 - Wiley Online Library
The widespread use of transition‐metal‐mediated C− H bond activation has altered the field
of organic synthesis. Notwithstanding the immense effect this strategy has had on classical …

Enantioselective Palladium‐Catalyzed Dearomative Cyclization for the Efficient Synthesis of Terpenes and Steroids

K Du, P Guo, Y Chen, Z Cao, Z Wang… - Angewandte Chemie …, 2015 - Wiley Online Library
A novel enantioselective palladium‐catalyzed dearomative cyclization has been developed
for the efficient construction of a series of chiral phenanthrenone derivatives bearing an all …