C–H activation
T Rogge, N Kaplaneris, N Chatani, J Kim… - Nature Reviews …, 2021 - nature.com
Transition metal-catalysed C–H activation has emerged as an increasingly powerful platform
for molecular syntheses, enabling applications to natural product syntheses, late-stage …
for molecular syntheses, enabling applications to natural product syntheses, late-stage …
Transition-metal catalyzed C–H activation as a means of synthesizing complex natural products
Over the past few decades, the advent of C–H activation has led to a rethink among
chemists about the synthetic strategies employed for multi-step transformations. Indeed …
chemists about the synthetic strategies employed for multi-step transformations. Indeed …
Recent applications of C–H functionalization in complex natural product synthesis
DJ Abrams, PA Provencher, EJ Sorensen - Chemical Society Reviews, 2018 - pubs.rsc.org
In this review, recent examples featuring C–H functionalization in the synthesis of complex
natural products are discussed. A focus is given to the way in which C–H functionalization …
natural products are discussed. A focus is given to the way in which C–H functionalization …
The medicinal chemist's toolbox for late stage functionalization of drug-like molecules
T Cernak, KD Dykstra, S Tyagarajan… - Chemical Society …, 2016 - pubs.rsc.org
The advent of modern C–H functionalization chemistries has enabled medicinal chemists to
consider a synthetic strategy, late stage functionalization (LSF), which utilizes the C–H …
consider a synthetic strategy, late stage functionalization (LSF), which utilizes the C–H …
Strategic application of C–H oxidation in natural product total synthesis
The oxidation of unactivated C–H bonds has emerged as an effective tactic in natural
product synthesis and has altered how chemists approach the synthesis of complex …
product synthesis and has altered how chemists approach the synthesis of complex …
Navigating the chiral pool in the total synthesis of complex terpene natural products
ZG Brill, ML Condakes, CP Ting, TJ Maimone - Chemical reviews, 2017 - ACS Publications
The pool of abundant chiral terpene building blocks (ie,“chiral pool terpenes”) has long
served as a starting point for the chemical synthesis of complex natural products, including …
served as a starting point for the chemical synthesis of complex natural products, including …
Collective approach to advancing C–H functionalization
HML Davies, D Morton - ACS Central Science, 2017 - ACS Publications
C–H functionalization is a very active research field that has attracted the interest of
scientists from many disciplines. This Outlook describes the collaborative efforts within the …
scientists from many disciplines. This Outlook describes the collaborative efforts within the …
Strategy evolution in a skeletal remodeling and C–H functionalization-based synthesis of the longiborneol sesquiterpenoids
RF Lusi, G Sennari, R Sarpong - Journal of the American …, 2022 - ACS Publications
Detailed herein are our synthesis studies of longiborneol and related natural products. Our
overarching goals of utilizing a “camphor first” strategy enabled by skeletal remodeling of …
overarching goals of utilizing a “camphor first” strategy enabled by skeletal remodeling of …
Natural product synthesis by C− H activation
The widespread use of transition‐metal‐mediated C− H bond activation has altered the field
of organic synthesis. Notwithstanding the immense effect this strategy has had on classical …
of organic synthesis. Notwithstanding the immense effect this strategy has had on classical …
Enantioselective Palladium‐Catalyzed Dearomative Cyclization for the Efficient Synthesis of Terpenes and Steroids
K Du, P Guo, Y Chen, Z Cao, Z Wang… - Angewandte Chemie …, 2015 - Wiley Online Library
A novel enantioselective palladium‐catalyzed dearomative cyclization has been developed
for the efficient construction of a series of chiral phenanthrenone derivatives bearing an all …
for the efficient construction of a series of chiral phenanthrenone derivatives bearing an all …