The genetic landscape of classical myeloproliferative neoplasm (MPN) is in large part
elucidated. The MPN-restricted driver mutations, including those in JAK2, calreticulin …

JAKs and STATs in Immunity, Immunodeficiency, and Cancer | New England Journal of Medicine
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Background Cancers result from the accumulation of somatic mutations, and their properties
are thought to reflect the sum of these mutations. However, little is known about the effect of …

Myeloproliferative neoplasms (MPNs) are a group of clonal disorders characterized by
aberrant hematopoietic proliferation and an increased tendency toward leukemic …

The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway is
central to signaling by cytokine receptors, a superfamily of more than 30 transmembrane …

Frameshift mutations in the calreticulin (CALR) gene are seen in about 30% of essential
thrombocythemia and myelofibrosis patients. To address the contribution of the CALR …

Myeloproliferative neoplasms (MPNs) are clonal disorders characterized by excessive
production of mature blood cells. In the majority of classic MPN—polycythemia vera …

Aging facilitates the expansion of hematopoietic stem cells (HSCs) carrying clonal
hematopoiesis-related somatic mutations and the development of myeloid malignancies …

Proinflammatory cytokines such as TNFα are elevated in patients with myeloproliferative
neoplasms (MPN), but their contribution to disease pathogenesis is unknown. Here we …

Increasing evidence shows that conventional cardiovascular risk factors are incompletely
predictive of cardiovascular disease, particularly in elderly individuals, suggesting that there …