Conduct disorder
Conduct disorder (CD) is a common and highly impairing psychiatric disorder that usually
emerges in childhood or adolescence and is characterized by severe antisocial and …
emerges in childhood or adolescence and is characterized by severe antisocial and …
The key role of epigenetics in human disease prevention and mitigation
AP Feinberg - New England Journal of Medicine, 2018 - Mass Medical Soc
Epigenetics in Disease Prevention and Mitigation Epigenetics is the regulation of gene
expression through alterations in DNA or associated factors (other than the DNA sequence) …
expression through alterations in DNA or associated factors (other than the DNA sequence) …
Principal Component Analyses (PCA)-based findings in population genetic studies are highly biased and must be reevaluated
E Elhaik - Scientific Reports, 2022 - nature.com
Abstract Principal Component Analysis (PCA) is a multivariate analysis that reduces the
complexity of datasets while preserving data covariance. The outcome can be visualized on …
complexity of datasets while preserving data covariance. The outcome can be visualized on …
Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology
W Van Rheenen, RAA Van Der Spek, MK Bakker… - Nature …, 2021 - nature.com
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with a lifetime risk
of one in 350 people and an unmet need for disease-modifying therapies. We conducted a …
of one in 350 people and an unmet need for disease-modifying therapies. We conducted a …
The DNA methylation in neurological diseases
DNA methylation is critical for the normal development and functioning of the human brain,
such as the proliferation and differentiation of neural stem cells, synaptic plasticity, neuronal …
such as the proliferation and differentiation of neural stem cells, synaptic plasticity, neuronal …
Guidance for DNA methylation studies: statistical insights from the Illumina EPIC array
Background There has been a steady increase in the number of studies aiming to identify
DNA methylation differences associated with complex phenotypes. Many of the challenges …
DNA methylation differences associated with complex phenotypes. Many of the challenges …
Biological hypotheses, risk factors, and biomarkers of schizophrenia
Z Fišar - Progress in Neuro-Psychopharmacology and …, 2023 - Elsevier
Both the discovery of biomarkers of schizophrenia and the verification of biological
hypotheses of schizophrenia are an essential part of the process of understanding the …
hypotheses of schizophrenia are an essential part of the process of understanding the …
A Bayesian framework for multiple trait colocalization from summary association statistics
Motivation Most genetic variants implicated in complex diseases by genome-wide
association studies (GWAS) are non-coding, making it challenging to understand the …
association studies (GWAS) are non-coding, making it challenging to understand the …
Characterizing genetic and environmental influences on variable DNA methylation using monozygotic and dizygotic twins
Variation in DNA methylation is being increasingly associated with health and disease
outcomes. Although DNA methylation is hypothesized to be a mechanism by which both …
outcomes. Although DNA methylation is hypothesized to be a mechanism by which both …
DNA methylation meta-analysis reveals cellular alterations in psychosis and markers of treatment-resistant schizophrenia
We performed a systematic analysis of blood DNA methylation profiles from 4483
participants from seven independent cohorts identifying differentially methylated positions …
participants from seven independent cohorts identifying differentially methylated positions …