A lack of gravity experienced during space flight has been shown to have profound effects
on human physiology including muscle atrophy, reductions in bone density and immune …

Osteoporosis is a chronical, systemic skeletal disorder characterized by an increase in bone
resorption, which leads to reduced bone density. The reduction in bone mineral density and …

A wide variety of bone diseases have hitherto been discovered, such as osteoporosis,
Paget's disease, osteopetrosis, and metastatic bone disease, which are not well defined in …

Introduction This post hoc analysis of the placebo-controlled phase 3 FRAME study
assessed the efficacy and safety of romosozumab in a subpopulation of Japanese …

Subcutaneous injection is a commonly used route of drug administration for both small
molecules and biologics. To facilitate the development of new subcutaneously administered …

Bone remodeling is a complex physiological process that spans across multiple spatial and
temporal scales and is regulated by both mechanical and hormonal cues. An imbalance …

Bone remodeling, expressed as bone formation and turnover, is a complex and dynamic
process closely related to its form and function. Different events, such as development …

Primary osteoporosis is closely linked to hormone deficiency, which disrupts the balance of
bone remodeling. It affects postmenopausal women but also significantly impacts older men …

Bone mechanobiology is the study of the physical, biological and mechanical processes that
continuously affect the multiscale multicellular system of the bone from the organ to the …

Osteoporosis (OP) is a chronic progressive bone disease which is characterized by
reduction of bone matrix volume and changes in the bone matrix properties which can …