Clathrin is best known for its contribution to clathrin-mediated endocytosis yet it also
participates to a diverse range of cellular functions. Key to this is clathrin's ability to …

Clathrin-mediated endocytosis is the main entry route for most cell surface receptors and
their ligands. It is regulated by clathrin-coated structures that are endowed with the ability to …

β-arrestins regulate many cellular functions including intracellular signaling and
desensitization of G protein–coupled receptors (GPCRs). Previous studies show that β …

Membrane tension plays an inhibitory role in clathrin-mediated endocytosis (CME) by
impeding the transition of flat plasma membrane to hemispherical clathrin-coated structures …

Specificity and sensitivity in biochemical reactions can be achieved through regulation of
equilibrium binding affinity or through proofreading mechanisms that allow for the …

Eukaryotic cells use clathrin-mediated endocytosis to take up a large range of extracellular
cargos. During endocytosis, a clathrin coat forms on the plasma membrane, but it remains …

Intracellular trafficking requires extensive changes in membrane morphology. Cells use
several distinct molecular factors and physical cues to remodel membranes. Here, we …

Clathrin-mediated endocytosis (CME) remains robust despite variation in plasma membrane
tension. Actin assembly-mediated force generation becomes essential for CME under high …

Tato práce se zabývá buněčnou endocytózou, se zaměřením na clathrinové váčky (CCPs)
za použití pokročilé mikroskopie Total Internal Reflection Fluorescence-Structured …