Recent trends in biocatalysis
D Yi, T Bayer, CPS Badenhorst, S Wu… - Chemical Society …, 2021 - pubs.rsc.org
Biocatalysis has undergone revolutionary progress in the past century. Benefited by the
integration of multidisciplinary technologies, natural enzymatic reactions are constantly …
integration of multidisciplinary technologies, natural enzymatic reactions are constantly …
Evolution and diversity of assembly-line polyketide synthases: Focus review
Assembly-line polyketide synthases (PKSs) are among the most complex protein
machineries known in nature, responsible for the biosynthesis of numerous compounds …
machineries known in nature, responsible for the biosynthesis of numerous compounds …
Synthetic biology to access and expand nature's chemical diversity
Bacterial genomes encode the biosynthetic potential to produce hundreds of thousands of
complex molecules with diverse applications, from medicine to agriculture and materials …
complex molecules with diverse applications, from medicine to agriculture and materials …
Collective approach to advancing C–H functionalization
HML Davies, D Morton - ACS Central Science, 2017 - ACS Publications
C–H functionalization is a very active research field that has attracted the interest of
scientists from many disciplines. This Outlook describes the collaborative efforts within the …
scientists from many disciplines. This Outlook describes the collaborative efforts within the …
Engineering strategies for rational polyketide synthase design
M Klaus, M Grininger - Natural product reports, 2018 - pubs.rsc.org
Covering: mid 1990s to 2018 Over the last two decades, diverse approaches have been
explored to generate new polyketides by engineering polyketide synthases (PKSs) …
explored to generate new polyketides by engineering polyketide synthases (PKSs) …
Development of transcription factor-based designer macrolide biosensors for metabolic engineering and synthetic biology
Macrolides are a large group of natural products that display broad and potent biological
activities and are biosynthesized by type I polyketide synthases (PKSs) and associated …
activities and are biosynthesized by type I polyketide synthases (PKSs) and associated …
Bacteria as genetically programmable producers of bioactive natural products
Next to plants, bacteria account for most of the biomass on Earth. They are found
everywhere, although certain species thrive only in specific ecological niches. These …
everywhere, although certain species thrive only in specific ecological niches. These …
[HTML][HTML] Engineering enzymatic assembly lines to produce new antibiotics
KAJ Bozhüyük, J Micklefield, B Wilkinson - Current opinion in microbiology, 2019 - Elsevier
Highlights•Many clinical antibiotics are natural products produced by thiotemplate-based
assembly line biosynthetic pathways.•Assembly line pathways provide an opportunity for …
assembly line biosynthetic pathways.•Assembly line pathways provide an opportunity for …
Diversity oriented biosynthesis via accelerated evolution of modular gene clusters
A Wlodek, SG Kendrew, NJ Coates, A Hold… - Nature …, 2017 - nature.com
Erythromycin, avermectin and rapamycin are clinically useful polyketide natural products
produced on modular polyketide synthase multienzymes by an assembly-line process in …
produced on modular polyketide synthase multienzymes by an assembly-line process in …
Module-Based Polyketide Synthase Engineering for de Novo Polyketide Biosynthesis
Polyketide retrobiosynthesis, where the biosynthetic pathway of a given polyketide can be
reversibly engineered due to the colinearity of the polyketide synthase (PKS) structure and …
reversibly engineered due to the colinearity of the polyketide synthase (PKS) structure and …