Long QT and short QT syndromes (LQTS and SQTS) are cardiac repolarization
abnormalities that are characterized by length perturbations of the QT interval as measured …

The molecular millennium has bestowed researchers with the essential tools to identify the
underlying genetic substrates for thousands of genetic disorders, most of which are rare and …

Background—Life-threatening disorders of heart rhythm may arise during infancy and can
result in the sudden and tragic death of a child. We performed exome sequencing on 2 …

Importance Intrauterine fetal death or stillbirth occurs in approximately 1 out of every 160
pregnancies and accounts for 50% of all perinatal deaths. Postmortem evaluation fails to …

Long QT syndrome (LQTS) refers to a group of “channelopathies”–disorders that affect
cardiac ion channels. The “family” concept of syndromes has been applied to the multiple …

Channelopathies are diseases caused by dysfunctional ion channels, due to either genetic
or acquired pathological factors. Inherited cardiac arrhythmic syndromes are among the …

The human fetal heart develops arrhythmias and conduction disturbances in response to
ischemia, inflammation, electrolyte disturbances, altered load states, structural defects …

Thousands die each year from sudden infant death syndrome (SIDS). Neither the cause nor
basis for varied prevalence in different populations is understood. While 2 cases have been …

Background—Fetal long QT syndrome (LQTS) is associated with complex arrhythmias
including torsades de pointes and 2° atrioventricular block. Sinus bradycardia has also been …

Objectives This study sought to determine the relationship between long QT syndrome
(LQTS) subtype (LTQ1, LTQ2, LTQ3) and postnatal cardiac events (CEs). Background LQTS …