Cancer is a multistep disease driven by the activation of specific oncogenic pathways
concomitantly with the loss of function of tumor suppressor genes that act as sentinels to …

The control of body and organ growth is essential for the development of adults with proper
size and proportions, which is important for survival and reproduction. In animals, adult body …

This review is intended to provide a broad outline of the biological and molecular functions
of MYC as well as of the larger protein network within which MYC operates. We present a …

Just over 25 years ago, MYC, the human homologue of a retroviral oncogene, was
identified. Since that time, MYC research has been intense and the advances impressive …

The MYC proto-oncogene is frequently deregulated in human cancers, activating genetic
programs that orchestrate biological processes to promote growth and proliferation. Altered …

▪ Abstract The Myc/Max/Mad network comprises a group of transcription factors whose
distinct interactions result in gene-specific transcriptional activation or repression. A great …

The discovery of anticancer drugs is now driven by the numerous molecular alterations
identified in tumor cells over the past decade. To exploit these alterations, it is necessary to …

The control of growth is fundamental to the developing metazoan. Here, we show that
CHICO, a Drosophila homolog of vertebrate IRS1–4, plays an essential role in the control of …

The interaction of MYC and hypoxia inducible factors (HIFs) under physiological, non-
tumorigenic conditions provides insights into normal homeostatic cellular responses to low …

The c-Myc and E2F transcription factors are among the most potent regulators of cell cycle
progression in higher eukaryotes. This report describes the isolation of a novel, highly …