Scientists in this field often joke," If you don't have a mechanism, say it's ROS." Seemingly
connected to every biological process ever described, reactive oxygen species (ROS) have …

Impaired redox metabolism is a key contributor to the etiology of many diseases, including
primary mitochondrial disorders, cancer, neurodegeneration and aging. However …

Dietary restriction (DR) protocols frequently employ intermittent fasting. Following a period of
fasting, meal consumption increases lipogenic gene expression, including that of NADPH …

Cancer cells depend on nicotinamide adenine dinucleotide phosphate (NADPH) to combat
oxidative stress and support reductive biosynthesis. One major NADPH production route is …

Inflammatory bowel diseases are characterized by the chronic relapsing inflammation of the
gastrointestinal tract. While the molecular causality between endoplasmic reticulum (ER) …

Cellular and subcellular metabolic activities are crucial processes involved in the regulation
of intracellular homeostasis, including cellular and subcellular signaling pathways …

Cancer cells depend on nicotinamide adenine dinucleotide phosphate (NADPH) to combat
oxidative stress and support reductive biosynthesis. One major NAPDH production route is …

Identification of compounds to modulate NADPH metabolism is crucial for understanding
complex diseases and developing effective therapies. However, the complex nature of …

Background: DHEA is a steroid hormone produced by the gonads, adrenal cortex, brain, and
gastrointestinal tract. While the anti-obesity, anti-atherosclerosis, anti-cancer, and memory …

Recent investigations have revealed that oxidative stress can lead to neuronal damage and
disrupt mitochondrial and endoplasmic reticulum functions after intracerebral hemorrhage …