Molecular heterogeneity and immunosuppressive microenvironment in glioblastoma
Glioblastoma (GBM) is the most aggressive primary brain tumor in adults, with a poor
prognosis, despite surgical resection combined with radio-and chemotherapy. The major …
prognosis, despite surgical resection combined with radio-and chemotherapy. The major …
Current and future trends on diagnosis and prognosis of glioblastoma: from molecular biology to proteomics
Glioblastoma multiforme is the most aggressive malignant tumor of the central nervous
system. Due to the absence of effective pharmacological and surgical treatments, the …
system. Due to the absence of effective pharmacological and surgical treatments, the …
Molecular control of oligodendrocyte development
Myelin is a multilayer lipid membrane structure that wraps and insulates axons, allowing for
the efficient propagation of action potentials. During developmental myelination of the …
the efficient propagation of action potentials. During developmental myelination of the …
TNF-α-producing macrophages determine subtype identity and prognosis via AP1 enhancer reprogramming in pancreatic cancer
M Tu, L Klein, E Espinet, T Georgomanolis, F Wegwitz… - Nature cancer, 2021 - nature.com
Large-scale genomic profiling of pancreatic cancer (PDAC) has revealed two distinct
subtypes:'classical'and 'basal-like'. Their variable coexistence within the stromal immune …
subtypes:'classical'and 'basal-like'. Their variable coexistence within the stromal immune …
Neuronal and tumourigenic boundaries of glioblastoma plasticity
Glioblastoma (GBM) remains the most lethal primary brain cancer largely due to recurrence
of treatment-resistant disease. Current therapies are ultimately ineffective as GBM tumour …
of treatment-resistant disease. Current therapies are ultimately ineffective as GBM tumour …
Important shapeshifter: mechanisms allowing astrocytes to respond to the changing nervous system during development, injury and disease
J Schiweck, BJ Eickholt, K Murk - Frontiers in cellular neuroscience, 2018 - frontiersin.org
Astrocytes are the most prevalent glial cells in the brain. Historically considered as “merely
supporting” neurons, recent research has shown that astrocytes actively participate in a …
supporting” neurons, recent research has shown that astrocytes actively participate in a …
A three-dimensional (3D) organotypic microfluidic model for glioma stem cells–Vascular interactions
Glioblastoma (GBM) is one of the deadliest forms of cancer. Despite many treatment options,
prognosis of GBM remains dismal with a 5-year survival rate of 4.7%. Even then, tumors …
prognosis of GBM remains dismal with a 5-year survival rate of 4.7%. Even then, tumors …
Oncogenes activate an autonomous transcriptional regulatory circuit that drives glioblastoma
Efforts to identify and target glioblastoma (GBM) drivers have primarily focused on receptor
tyrosine kinases (RTKs). Clinical benefits, however, have been elusive. Here, we identify an …
tyrosine kinases (RTKs). Clinical benefits, however, have been elusive. Here, we identify an …
Developmentally regulated signaling pathways in glioma invasion
S Mehta, C Lo Cascio - Cellular and Molecular Life Sciences, 2018 - Springer
Malignant gliomas are the most common, infiltrative, and lethal primary brain tumors
affecting the adult population. The grim prognosis for this disease is due to a combination of …
affecting the adult population. The grim prognosis for this disease is due to a combination of …
The role of neurodevelopmental pathways in brain tumors
RN Curry, SM Glasgow - Frontiers in Cell and Developmental Biology, 2021 - frontiersin.org
Disruptions to developmental cell signaling pathways and transcriptional cascades have
been implicated in tumor initiation, maintenance and progression. Resurgence of aberrant …
been implicated in tumor initiation, maintenance and progression. Resurgence of aberrant …