Enhancer of zeste homolog 2 (EZH2) is enzymatic catalytic subunit of polycomb repressive
complex 2 (PRC2) that can alter downstream target genes expression by trimethylation of …

Non-coding RNAs (ncRNAs) are a large family of RNA molecules with no capability in
encoding proteins. However, they participate in developmental and biological processes …

Epigenetic alternations concern heritable yet reversible changes in histone or DNA
modifications that regulate gene activity beyond the underlying sequence. Epigenetic …

Recent genomic studies have resulted in an emerging understanding of the role of
chromatin regulators in the development of cancer. EZH2, a histone methyl transferase …

Epigenetic drug discovery field has evidenced significant advancement in the recent times.
A plethora of small molecule inhibitors have progressed to clinical stage investigations and …

Diffuse intrinsic pontine glioma (DIPG) is an aggressive brain tumor that is located in the
pons and primarily affects children. Nearly 80% of DIPGs harbor mutations in histone H3 …

Germinal centres (GCs) are involved in the selection of B cells secreting high-affinity
antibodies and are also the origin of most human B cell lymphomas. Recent progress has …

The term epigenetics is defined as heritable changes in gene expression that are not due to
alterations of the DNA sequence. In the last years, it has become more and more evident …

Two recurrent mutations, K27M and G34R/V, within histone variant H3. 3 were recently
identified in∼ 50% of pHGGs. Both mutations define clinically and biologically distinct …

The EZH2 histone methyltransferase is highly expressed in germinal center (GC) B cells and
targeted by somatic mutations in B cell lymphomas. Here, we find that EZH2 deletion or …