Purinergic signalling, ie, the role of nucleotides as extracellular signalling molecules, was
proposed in 1972. However, this concept was not well accepted until the early 1990's when …

Seven P2X ion channel nucleotide receptor subtypes have been cloned and characterised.
P2X7 receptors (P2X7R) are unusual in that there are extra amino acids in the intracellular …

Nucleotides are released from all cells through regulated pathways or as a result of plasma
membrane damage or cell death. Outside the cell, nucleotides act as signalling molecules …

P2X7 receptor, a purinergic receptor family member, is abundantly expressed on many cells,
including immune, muscle, bone, neuron, and glia. It acts as an ATP-activated cation …

The Pacific region, also referred to as Oceania, is a geographically widespread region
populated by people of diverse cultures and ethnicities. Indigenous people in the region …

Background Multidrug-resistant (MDR) tuberculosis has low treatment success rates, and
new treatment strategies are needed. We explored whether treatment with active vitamin D3 …

The P2X7 receptor, a member of the P2X purinergic receptor family, is a non-selective ion
channel. Over the years, it has been associated with various biological functions, from …

Stimulation of the P2X7 receptor by extracellular adenosine 5'-triphosphate induces a series
of responses in the organism, exceptionally protein cascades related to the proinflammatory …

Immune responses are essential for the protection of the host against external dangers or
infections and are normally efficient in the clearance of invading microbes. However, some …

The high incidence of tuberculosis (TB) in the world, especially in developing countries, the
resurgence of TB in industrialized countries, and the global increase in the prevalence of …