Toxin-antitoxin systems in bacteria and archaea

Y Yamaguchi, JH Park, M Inouye - Annual review of genetics, 2011 - annualreviews.org
Almost all bacteria and many archaea contain genes whose expression inhibits cell growth
and may lead to cell death when overproduced, reminiscent of apoptotic genes in higher …

Toxin–antitoxin systems: biology, identification, and application

SJ Unterholzner, B Poppenberger… - Mobile genetic …, 2013 - Taylor & Francis
Toxin–antitoxin (TA) systems are small genetic elements composed of a toxin gene and its
cognate antitoxin. The toxins of all known TA systems are proteins while the antitoxins are …

[HTML][HTML] Bacterial toxin-antitoxin modules: classification, functions, and association with persistence

G Singh, M Yadav, C Ghosh, JS Rathore - Current Research in Microbial …, 2021 - Elsevier
Toxin-antitoxin (TA) modules are ubiquitous gene loci among bacteria and are comprised of
a toxin part and its cognate antitoxin part. Under normal physiological conditions, antitoxin …

To be or not to be: regulation of restriction–modification systems and other toxin–antitoxin systems

I Mruk, I Kobayashi - Nucleic acids research, 2014 - academic.oup.com
One of the simplest classes of genes involved in programmed death is that containing the
toxin–antitoxin (TA) systems of prokaryotes. These systems are composed of an intracellular …

Toxins-antitoxins: diversity, evolution and function

F Hayes, L Van Melderen - Critical reviews in biochemistry and …, 2011 - Taylor & Francis
Genes for toxin-antitoxin (TA) complexes are widespread in prokaryote genomes, and
species frequently possess tens of plasmid and chromosomal TA loci. The complexes are …

Toxin–antitoxin systems are ubiquitous and versatile modulators of prokaryotic cell fate

CF Schuster, R Bertram - FEMS microbiology letters, 2013 - academic.oup.com
Toxin–antitoxin (TA) systems are small genetic elements found on plasmids or
chromosomes of countless bacteria, archaea, and possibly also unicellular fungi. Under …

Keeping the wolves at bay: antitoxins of prokaryotic type II toxin-antitoxin systems

WT Chan, M Espinosa, CC Yeo - Frontiers in molecular biosciences, 2016 - frontiersin.org
In their initial stages of discovery, prokaryotic toxin-antitoxin (TA) systems were confined to
bacterial plasmids where they function to mediate the maintenance and stability of usually …

Structure, biology, and therapeutic application of toxin–antitoxin systems in pathogenic bacteria

KY Lee, BJ Lee - Toxins, 2016 - mdpi.com
Bacterial toxin–antitoxin (TA) systems have received increasing attention for their diverse
identities, structures, and functional implications in cell cycle arrest and survival against …

Artificial activation of toxin–antitoxin systems as an antibacterial strategy

JJ Williams, PJ Hergenrother - Trends in microbiology, 2012 - cell.com
Toxin–antitoxin (TA) systems are unique modules that effect plasmid stabilization via post-
segregational killing of the bacterial host. The genes encoding TA systems also exist on …

Regulating toxin-antitoxin expression: controlled detonation of intracellular molecular timebombs

F Hayes, B Kędzierska - Toxins, 2014 - mdpi.com
Genes for toxin-antitoxin (TA) complexes are widely disseminated in bacteria, including in
pathogenic and antibiotic resistant species. The toxins are liberated from association with …