Toxin-antitoxin systems in bacteria and archaea
Almost all bacteria and many archaea contain genes whose expression inhibits cell growth
and may lead to cell death when overproduced, reminiscent of apoptotic genes in higher …
and may lead to cell death when overproduced, reminiscent of apoptotic genes in higher …
Toxin–antitoxin systems: biology, identification, and application
SJ Unterholzner, B Poppenberger… - Mobile genetic …, 2013 - Taylor & Francis
Toxin–antitoxin (TA) systems are small genetic elements composed of a toxin gene and its
cognate antitoxin. The toxins of all known TA systems are proteins while the antitoxins are …
cognate antitoxin. The toxins of all known TA systems are proteins while the antitoxins are …
[HTML][HTML] Bacterial toxin-antitoxin modules: classification, functions, and association with persistence
Toxin-antitoxin (TA) modules are ubiquitous gene loci among bacteria and are comprised of
a toxin part and its cognate antitoxin part. Under normal physiological conditions, antitoxin …
a toxin part and its cognate antitoxin part. Under normal physiological conditions, antitoxin …
To be or not to be: regulation of restriction–modification systems and other toxin–antitoxin systems
I Mruk, I Kobayashi - Nucleic acids research, 2014 - academic.oup.com
One of the simplest classes of genes involved in programmed death is that containing the
toxin–antitoxin (TA) systems of prokaryotes. These systems are composed of an intracellular …
toxin–antitoxin (TA) systems of prokaryotes. These systems are composed of an intracellular …
Toxins-antitoxins: diversity, evolution and function
F Hayes, L Van Melderen - Critical reviews in biochemistry and …, 2011 - Taylor & Francis
Genes for toxin-antitoxin (TA) complexes are widespread in prokaryote genomes, and
species frequently possess tens of plasmid and chromosomal TA loci. The complexes are …
species frequently possess tens of plasmid and chromosomal TA loci. The complexes are …
Toxin–antitoxin systems are ubiquitous and versatile modulators of prokaryotic cell fate
CF Schuster, R Bertram - FEMS microbiology letters, 2013 - academic.oup.com
Toxin–antitoxin (TA) systems are small genetic elements found on plasmids or
chromosomes of countless bacteria, archaea, and possibly also unicellular fungi. Under …
chromosomes of countless bacteria, archaea, and possibly also unicellular fungi. Under …
Keeping the wolves at bay: antitoxins of prokaryotic type II toxin-antitoxin systems
In their initial stages of discovery, prokaryotic toxin-antitoxin (TA) systems were confined to
bacterial plasmids where they function to mediate the maintenance and stability of usually …
bacterial plasmids where they function to mediate the maintenance and stability of usually …
Structure, biology, and therapeutic application of toxin–antitoxin systems in pathogenic bacteria
KY Lee, BJ Lee - Toxins, 2016 - mdpi.com
Bacterial toxin–antitoxin (TA) systems have received increasing attention for their diverse
identities, structures, and functional implications in cell cycle arrest and survival against …
identities, structures, and functional implications in cell cycle arrest and survival against …
Artificial activation of toxin–antitoxin systems as an antibacterial strategy
JJ Williams, PJ Hergenrother - Trends in microbiology, 2012 - cell.com
Toxin–antitoxin (TA) systems are unique modules that effect plasmid stabilization via post-
segregational killing of the bacterial host. The genes encoding TA systems also exist on …
segregational killing of the bacterial host. The genes encoding TA systems also exist on …
Regulating toxin-antitoxin expression: controlled detonation of intracellular molecular timebombs
F Hayes, B Kędzierska - Toxins, 2014 - mdpi.com
Genes for toxin-antitoxin (TA) complexes are widely disseminated in bacteria, including in
pathogenic and antibiotic resistant species. The toxins are liberated from association with …
pathogenic and antibiotic resistant species. The toxins are liberated from association with …