Multiple drug resistance of cancer cells is multifactorial. A microarray technique may provide
information about new candidate genes playing a role in drug resistance. Drug membrane …

Diterpene compounds specially macrocyclic ones comprising jatrophane, lathyrane,
terracinolide, ingenane, pepluane, paraliane, and segetane skeletons occurring in plants of …

Data on medical applications of cerium oxide nanoparticles CeO 2 (CONP) are promising,
yet information regarding their action in cells is incomplete and there are conflicting reports …

We describe the design, synthesis, and antitumor activity of an 18 carbon α, ω-dicarboxylic
acid monoconjugated via an ester linkage to paclitaxel (PTX). This 1, 18-octadecanedioic …

Drug resistance is a main obstacle for the successful chemotherapy of lung cancer. In this
work, a new co-delivery system, P85-PEI/TPGS/PTX/shSur complex nanoparticles (PTPNs) …

Ovarian cancer is the leading cause of death among gynaecological malignancies. Multiple
drug resistance makes cancer cells insensitive to chemotherapy. In this study, we developed …

Ovarian cancer is characterized by the higher mortality among gynecological cancers. In
results of MDR development during chemotherapy cancer cells become resistant to further …

Background Multiple drug resistance (MDR) of cancer cells is the main reason of intrinsic or
acquired insensitivity to chemotherapy in many cancers. In this study we used ovarian …

The discovery that survivin, a small anti-apoptotic protein, is involved in chemoresistance,
opens a new scenario to overcome the drug resistance in cancer. It was shown that siRNA …

Elesclomol (ES), a copper-binding ionophore, forms an ES–Cu complex with copper ions
(Cu (II)). ES–Cu has been proven to induce mitochondrial oxidative stress and copper …