Aminoglycoside antibiotics are employed clinically because of their potent bactericidal
activities, less bacterial resistance, post-antibiotic effects and low cost. However, drugs …

Aims Nephrotoxicity is the hallmark of anti-neoplastic drug metabolism that causes oxidative
stress. External chemical agents and prescription drugs release copious amounts of free …

Biol. Pharm. Bull. 32(1): 61-67 (2009) Page 1 Gentamicin (GM) is an aminoglycoside antibiotic
that is very effective in treating life-threatening gram-negative infections.Unfortunately, 30% of …

Resveratrol (3, 5, 4′‐trihydroxystilbene), a natural polyphenolic compound found in grapes
and red wine, is reported to have beneficial effects on cardiovascular diseases, including …

Quercetin (Q) is formulated into oil-in-water F127 microemulsions to improve its
bioavailability. The size of the Q-loaded microemulsions system was about 8 nm by dynamic …

The disruption of balance between production of reactive oxygen species and antioxidant
systems in favor of the oxidants is termed oxidative stress (OS). To counteract the damaging …

Aims Gentamicin (GEN) is one of the most valuable aminoglycoside antibiotics utilized
against life-threatening bacterial infections. Unfortunately, GEN-induced nephrotoxicity …

Kidney diseases constitute a worldwide public health problem, contributing to morbidity and
mortality. The present study aimed to provide an overview of the published data regarding …

Vitis vinifera (grape) is one of the “most‐produced fruit” in the world. Grape seeds are a
valuable source of phenolic compounds including resveratrol (RSV). Grape and one of its …

Introduction: Aminoglycosides have been long used for antibacterial treatment and are still
commonly used in clinical practice. Despite their extensive application and positive effects …