Tumor abnormality-oriented nanomedicine design

Q Zhou, J Xiang, N Qiu, Y Wang, Y Piao, S Shao… - Chemical …, 2023 - ACS Publications
Anticancer nanomedicines have been proven effective in mitigating the side effects of
chemotherapeutic drugs. However, challenges remain in augmenting their therapeutic …

Mechanical properties of whole-body soft human tissues: a review

G Singh, A Chanda - Biomedical Materials, 2021 - iopscience.iop.org
The mechanical properties of soft tissues play a key role in studying human injuries and their
mitigation strategies. While such properties are indispensable for computational modelling …

Challenges of applying multicellular tumor spheroids in preclinical phase

SJ Han, S Kwon, KS Kim - Cancer cell international, 2021 - Springer
Abstract The three-dimensional (3D) multicellular tumor spheroids (MCTs) model is
becoming an essential tool in cancer research as it expresses an intermediate complexity …

A history of exploring cancer in context

S Maman, IP Witz - Nature Reviews Cancer, 2018 - nature.com
The concept that progression of cancer is regulated by interactions of cancer cells with their
microenvironment was postulated by Stephen Paget over a century ago. Contemporary …

Shape‐memory polymers for biomedical applications

J Delaey, P Dubruel… - Advanced Functional …, 2020 - Wiley Online Library
One of the most promising fields for shape‐memory polymers is the biomedical field. Shape‐
memory polymers that can be triggered by various (physiological) conditions such as …

Reengineering the physical microenvironment of tumors to improve drug delivery and efficacy: from mathematical modeling to bench to bedside

T Stylianopoulos, LL Munn, RK Jain - Trends in cancer, 2018 - cell.com
Physical forces have a crucial role in tumor progression and cancer treatment. The
application of principles of engineering and physical sciences to oncology has provided …

Tissue–electronics interfaces: from implantable devices to engineered tissues

R Feiner, T Dvir - Nature Reviews Materials, 2017 - nature.com
Biomedical electronic devices are interfaced with the human body to extract precise medical
data and to interfere with tissue function by providing electrical stimuli. In this Review, we …

Human breast cancer invasion and aggression correlates with ECM stiffening and immune cell infiltration

I Acerbi, L Cassereau, I Dean, Q Shi, A Au… - Integrative …, 2015 - academic.oup.com
Tumors are stiff and data suggest that the extracellular matrix stiffening that correlates with
experimental mammary malignancy drives tumor invasion and metastasis. Nevertheless, the …

Tumor stiffening reversion through collagen crosslinking inhibition improves T cell migration and anti-PD-1 treatment

A Nicolas-Boluda, J Vaquero, L Vimeux, T Guilbert… - Elife, 2021 - elifesciences.org
Only a fraction of cancer patients benefits from immune checkpoint inhibitors. This may be
partly due to the dense extracellular matrix (ECM) that forms a barrier for T cells. Comparing …

EFSUMB guidelines and recommendations on the clinical use of ultrasound elastography. Part 2: Clinical applications

D Cosgrove, F Piscaglia, J Bamber… - Ultraschall in der …, 2013 - thieme-connect.com
The clinical part of these Guidelines and Recommendations produced under the auspices of
the European Federation of Societies for Ultrasound in Medicine and Biology EFSUMB …