Biocatalysis is a highly valued enabling technology for pharmaceutical research and
development as it can unlock synthetic routes to complex chiral motifs with unparalleled …

Enzyme catalysis is gaining increasing importance in synthetic chemistry. Nowadays, the
growing number of biocatalysts accessible by means of bioinformatics and enzyme …

Fluorine is a key element in the synthesis of molecules broadly used in medicine, agriculture
and materials. Addition of fluorine to organic structures represents a unique strategy for …

We previously reviewed the use of 19 F NMR in the broad field of chemical biology [Cobb,
SL; Murphy, CD J. Fluorine Chem. 2009, 130, 132–140] and present here a summary of the …

Highlights•Halogenation is a powerful strategy to tune physicochemical features of organic
molecules.•Synthetic metabolism can be tailored for the incorporation of halogen …

Strategic replacement of protons with fluorine atoms or functional groups with fluorine‐
containing fragments has proven a powerful strategy to optimize the activity of therapeutic …

The presence of mineral fluoride (F−) in the environment has both a geogenic and
anthropogenic origin, and the halide has been described to be toxic in virtually all living …

The relatively narrow spectrum of chemical elements within the microbial 'biochemical
palate'limits the reach of biotechnology, because several added-value compounds can only …

Fluorine is an important atom in medicinal chemistry and agrochemistry, and the
fluoromethyl group, an isostere for various functional groups, can improve the metabolic …

Fluorinated compounds are widely used in the fields of molecular imaging, pharmaceuticals,
and materials. Fluorinated natural products in nature are rare, and the introduction of …