Current practice and evolving concepts in septic shock resuscitation
Clinical and pathophysiological understanding of septic shock has progressed exponentially
in the previous decades, translating into a steady decrease in septic shock-related morbidity …
in the previous decades, translating into a steady decrease in septic shock-related morbidity …
Management of sepsis and septic shock in the emergency department
F Gavelli, LM Castello, GC Avanzi - Internal and emergency medicine, 2021 - Springer
Early management of sepsis and septic shock is crucial for patients' prognosis. As the
Emergency Department (ED) is the place where the first medical contact for septic patients is …
Emergency Department (ED) is the place where the first medical contact for septic patients is …
Effective hemodynamic monitoring
Hemodynamic monitoring is the centerpiece of patient monitoring in acute care settings. Its
effectiveness in terms of improved patient outcomes is difficult to quantify. This review …
effectiveness in terms of improved patient outcomes is difficult to quantify. This review …
The future of intensive care: the study of the microcirculation will help to guide our therapies
The goal of hemodynamic resuscitation is to optimize the microcirculation of organs to meet
their oxygen and metabolic needs. Clinicians are currently blind to what is happening in the …
their oxygen and metabolic needs. Clinicians are currently blind to what is happening in the …
A plea for personalization of the hemodynamic management of septic shock
Although guidelines provide excellent expert guidance for managing patients with septic
shock, they leave room for personalization according to patients' condition. Hemodynamic …
shock, they leave room for personalization according to patients' condition. Hemodynamic …
Using Bayesian methods to augment the interpretation of critical care trials. An overview of theory and example reanalysis of the alveolar recruitment for acute …
Most randomized trials are designed and analyzed using frequentist statistical approaches
such as null hypothesis testing and P values. Conceptually, P values are cumbersome to …
such as null hypothesis testing and P values. Conceptually, P values are cumbersome to …
Randomised clinical trials in critical care: past, present and future
Randomised clinical trials (RCTs) are the gold standard for providing unbiased evidence of
intervention effects. Here, we provide an overview of the history of RCTs and discuss the …
intervention effects. Here, we provide an overview of the history of RCTs and discuss the …
Efficacy of awake prone positioning in patients with covid-19 related hypoxemic respiratory failure: systematic review and meta-analysis of randomized trials
Objective To determine the efficacy and safety of awake prone positioning versus usual care
in non-intubated adults with hypoxemic respiratory failure due to covid-19. Design …
in non-intubated adults with hypoxemic respiratory failure due to covid-19. Design …
Fluid therapy for critically ill adults with sepsis: a review
Importance Approximately 20% to 30% of patients admitted to an intensive care unit have
sepsis. While fluid therapy typically begins in the emergency department, intravenous fluids …
sepsis. While fluid therapy typically begins in the emergency department, intravenous fluids …
Clinical trials in critical care: can a Bayesian approach enhance clinical and scientific decision making?
Recent Bayesian reanalyses of prominent trials in critical illness have generated controversy
by contradicting the initial conclusions based on conventional frequentist analyses. Many …
by contradicting the initial conclusions based on conventional frequentist analyses. Many …