Across complex, multi-time and-length scale biological systems, redundancy confers
robustness and resilience, enabling adaptation and increasing survival under dynamic …

Osteoporosis, a condition of skeletal decline that undermines quality of life, is treated with
pharmacological interventions that are associated with poor adherence and adverse effects …

Lamellipodia and ruffles are veil-shaped cell protrusions composed of a highly branched
actin filament meshwork assembled by the Arp2/3 complex. These structures not only …

Mesenchymal stem cells (MSCs) have the capacity to differentiate into multiple lineages
including osteogenic and adipogenic lineages. An increasing number of studies have …

Mesenchymal stem cells (MSCs) from adult tissues are promising candidates for
personalized cell therapy and tissue engineering. Significant progress was achieved in our …

Stem cells in their natural microenvironment are exposed to biochemical and biophysical
cues emerging from the extracellular matrix (ECM) and neighboring cells. In particular …

During bone marrow stromal cell (BMSC) differentiation, both Wnt signaling and the
development of a rigid cytoskeleton promote commitment to the osteoblastic over …

Epigenetic mechanisms control skeletal development and osteoblast differentiation.
Pharmacological inhibition of the histone 3 Lys-27 (H3K27) methyltransferase enhancer of …

An understanding of the cytoskeleton's importance in stem cells is essential for their
manipulation and further clinical application. The cytoskeleton is crucial in stem cell biology …

Abstract βcatenin acts as a primary intracellular signal transducer for mechanical and Wnt
signaling pathways to control cell function and fate. Regulation of βcatenin in the cytoplasm …