[HTML][HTML] Kidney injury in COVID-19 patients, drug development and their renal complications: Review study

ZM Yarijani, H Najafi - Biomedicine & Pharmacotherapy, 2021 - Elsevier
Since December 2019, the world was encountered a new disease called coronavirus
disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 …

Pharmacometrics: A New Era of Pharmacotherapy and Drug Development in Low‐and Middle‐Income Countries

M Usman, S Khadka, M Saleem… - Advances in …, 2023 - Wiley Online Library
Pharmacotherapy, in many cases, is practiced at a suboptimal level of performance in low‐
and middle‐income countries (LMICs) although stupendous amounts of data are available …

Hydroxychloroquine for prophylaxis of COVID-19 in health workers: A randomized clinical trial

J Rojas-Serrano, AM Portillo-Vásquez… - PLoS …, 2022 - journals.plos.org
Introduction Health care workers are at high risk of being infected with the severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2). Our aim is to evaluate the efficacy and …

Predicted Environmental Risk Assessment of Antimicrobials with Increased Consumption in Portugal during the COVID-19 Pandemic; The Groundwork for the …

A Almeida, C De Mello-Sampayo, A Lopes… - Antibiotics, 2023 - mdpi.com
The environmental release of antimicrobial pharmaceuticals is an imminent threat due to
ecological impacts and microbial resistance phenomena. The recent COVID-19 outbreak …

Hydroxychloroquine plus azithromycin early treatment of mild COVID-19 in an outpatient setting: a randomized, double-blinded, placebo-controlled clinical trial …

C Rodrigues, RS Freitas-Santos, JE Levi… - International journal of …, 2021 - Elsevier
Background Hydroxychloroquine has shown potential to block viral replication of SARS-CoV-
2 in some in vitro studies. This randomised, double-blinded, placebo controlled clinical trial …

In vitro evaluation of the impact of Covid-19 therapeutic agents on the hydrolysis of the antiviral prodrug remdesivir

Q Zhang, PW Melchert, JS Markowitz - Chemico-Biological Interactions, 2022 - Elsevier
Abstract Remdesivir (RDV, Veklury®) is an FDA-approved prodrug for the treatment of
hospitalized patients with COVID-19. Recent in vitro studies have indicated that human …

Hydrogen-oxygen therapy alleviates clinical symptoms in twelve patients hospitalized with COVID-19: A retrospective study of medical records

P Luo, Y Ding, Y He, D Chen, Q He, Z Huang, S Huang… - Medicine, 2022 - journals.lww.com
A global public health crisis caused by the 2019 novel coronavirus disease (COVID-19)
leads to considerable morbidity and mortality, which bring great challenge to respiratory …

Hydroxychloroquine does not function as a direct zinc ionophore

ON Kavanagh, S Bhattacharya, L Marchetti, R Elmes… - Pharmaceutics, 2022 - mdpi.com
Drug-mediated correction of abnormal biological zinc homeostasis could provide new routes
to treating neurodegeneration, cancer, and viral infections. Designing therapeutics to …

Tolerability and pharmacokinetic evaluation of inhaled dry powder hydroxychloroquine in healthy volunteers

YA de Reus, P Hagedoorn, MGG Sturkenboom… - Plos one, 2022 - journals.plos.org
Rationale Inhaled antimicrobials enable high local concentrations where needed and,
compared to orally administration, greatly reduce the potential for systemic side effects. In …

Acute and subacute oral toxicity of artemisinin-hydroxychloroquine sulfate tablets in rats

X Li, X Liao, X Yan, Y Yuan, Z Yuan, R Liu, Z Xu… - Regulatory Toxicology …, 2022 - Elsevier
Artemisinin-hydroxychloroquine sulfate tablets (AH) are considered a relatively inexpensive
and novel combination therapy for treating all forms of malaria, especially aminoquinoline …