Mechanisms of Aβ clearance and degradation by glial cells

M Ries, M Sastre - Frontiers in aging neuroscience, 2016 - frontiersin.org
Glial cells have a variety of functions in the brain, ranging from immune defense against
external and endogenous hazardous stimuli, regulation of synaptic formation, calcium …

Targeting autophagy for the treatment of Alzheimer's disease: challenges and opportunities

J Liu, L Li - Frontiers in molecular neuroscience, 2019 - frontiersin.org
Alzheimer's disease (AD) is the most common type of dementia which characterized by a
progressive loss of memory and cognitive function due to degeneration of synapses and …

Severe reactive astrocytes precipitate pathological hallmarks of Alzheimer's disease via H2O2 production

H Chun, H Im, YJ Kang, Y Kim, JH Shin, W Won… - Nature …, 2020 - nature.com
Although the pathological contributions of reactive astrocytes have been implicated in
Alzheimer's disease (AD), their in vivo functions remain elusive due to the lack of …

Loss of perivascular aquaporin-4 localization impairs glymphatic exchange and promotes amyloid β plaque formation in mice

M Simon, MX Wang, O Ismail, M Braun… - Alzheimer's research & …, 2022 - Springer
Background Slowed clearance of amyloid β (Aβ) is believed to underlie the development of
Aβ plaques that characterize Alzheimer's disease (AD). Aβ is cleared in part by the …

Microglia modulation with 1070-nm light attenuates Aβ burden and cognitive impairment in Alzheimer's disease mouse model

L Tao, Q Liu, F Zhang, Y Fu, X Zhu, X Weng… - Light: Science & …, 2021 - nature.com
Photobiomodulation, by utilizing low-power light in the visible and near-infrared spectra to
trigger biological responses in cells and tissues, has been considered as a possible …

Emerging roles of astrocytes in blood-brain barrier disruption upon amyloid-beta insults in Alzheimer's disease

Q Yue, MPM Hoi - Neural Regeneration Research, 2023 - journals.lww.com
Blood-brain barrier disruption occurs in the early stages of Alzheimer's disease. Recent
studies indicate a link between blood-brain barrier dysfunction and cognitive decline and …

Vasculo-neuronal coupling and neurovascular coupling at the neurovascular unit: impact of hypertension

JL Presa, F Saravia, Z Bagi, JA Filosa - Frontiers in physiology, 2020 - frontiersin.org
Components of the neurovascular unit (NVU) establish dynamic crosstalk that regulates
cerebral blood flow and maintain brain homeostasis. Here, we describe accumulating …

Innate immune alterations are elicited in microglial cells before plaque deposition in the Alzheimer's disease mouse model 5xFAD

A Boza-Serrano, Y Yang, A Paulus, T Deierborg - Scientific reports, 2018 - nature.com
Alzheimer's disease (AD) is the most common form of dementia characterized by the
formation of amyloid plaques (Aβ). Over the last decade, the important role of the innate …

Mechanistic and therapeutic role of NLRP3 inflammasome in the pathogenesis of Alzheimer's disease

D Jha, ENTP Bakker, R Kumar - Journal of neurochemistry, 2024 - Wiley Online Library
Abstract Alzheimer's disease (AD), a progressive neurodegenerative disorder, has emerged
as the most common form of dementia in the elderly. Several pathological hallmarks have …

Microglial autophagy is impaired by prolonged exposure to β-amyloid peptides: evidence from experimental models and Alzheimer's disease patients

C Pomilio, RM Gorojod, M Riudavets, A Vinuesa… - Geroscience, 2020 - Springer
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by the
presence of misfolded proteins, amyloid-β (Aβ) aggregates, and neuroinflammation in the …