Broadly neutralizing antibodies for treatment and prevention of HIV-1 infection
YZ Cohen, M Caskey - Current Opinion in HIV and AIDS, 2018 - journals.lww.com
Summary bNAbs may offer advantages over traditional ART for both the prevention and
treatment of HIV-1 infection. In addition, bNAbs may target the latent viral reservoir. bNAb …
treatment of HIV-1 infection. In addition, bNAbs may target the latent viral reservoir. bNAb …
Histone deacetylase inhibitor romidepsin induces HIV expression in CD4 T cells from patients on suppressive antiretroviral therapy at concentrations achieved by …
DG Wei, V Chiang, E Fyne, M Balakrishnan… - PLoS …, 2014 - journals.plos.org
Persistent latent reservoir of replication-competent proviruses in memory CD4 T cells is a
major obstacle to curing HIV infection. Pharmacological activation of HIV expression in …
major obstacle to curing HIV infection. Pharmacological activation of HIV expression in …
Targeted immune interventions for an HIV-1 cure
M Perreau, R Banga, G Pantaleo - Trends in molecular medicine, 2017 - cell.com
Combination antiretroviral therapy (cART) induces durable suppression of virus replication
but is unable to eradicate HIV. Invariably, virus rebound follows treatment interruption and …
but is unable to eradicate HIV. Invariably, virus rebound follows treatment interruption and …
Heightened resistance to host type 1 interferons characterizes HIV-1 at transmission and after antiretroviral therapy interruption
MVP Gondim, S Sherrill-Mix, F Bibollet-Ruche… - Science translational …, 2021 - science.org
Type 1 interferons (IFN-I) are potent innate antiviral effectors that constrain HIV-1
transmission. However, harnessing these cytokines for HIV-1 cure strategies has been …
transmission. However, harnessing these cytokines for HIV-1 cure strategies has been …
Pegylated Interferon alfa-2a monotherapy results in suppression of HIV type 1 replication and decreased cell-associated HIV DNA integration
L Azzoni, AS Foulkes, E Papasavvas… - The Journal of …, 2013 - academic.oup.com
Abstract Background. Antiretroviral therapy (ART)–mediated immune reconstitution fails to
restore the capacity of the immune system to spontaneously control human …
restore the capacity of the immune system to spontaneously control human …
Targeting HIV reservoir in infected CD4 T cells by dual-affinity re-targeting molecules (DARTs) that bind HIV envelope and recruit cytotoxic T cells
DD Sloan, CYK Lam, A Irrinki, L Liu, A Tsai… - PLoS …, 2015 - journals.plos.org
HIV reservoirs and production of viral antigens are not eliminated in chronically infected
participants treated with combination antiretroviral therapy (cART). Novel therapeutic …
participants treated with combination antiretroviral therapy (cART). Novel therapeutic …
Antiviral effects of autologous CD4 T cells genetically modified with a conditionally replicating lentiviral vector expressing long antisense to HIV
P Tebas, D Stein, G Binder-Scholl… - Blood, The Journal …, 2013 - ashpublications.org
We report the safety and tolerability of 87 infusions of lentiviral vector–modified autologous
CD4 T cells (VRX496-T; trade name, Lexgenleucel-T) in 17 HIV patients with well-controlled …
CD4 T cells (VRX496-T; trade name, Lexgenleucel-T) in 17 HIV patients with well-controlled …
Non-invasive plasma glycomic and metabolic biomarkers of post-treatment control of HIV
Non-invasive biomarkers that predict HIV remission after antiretroviral therapy (ART)
interruption are urgently needed. Such biomarkers can improve the safety of analytic …
interruption are urgently needed. Such biomarkers can improve the safety of analytic …
A phase I/IIa immunotherapy trial of HIV-1-infected patients with Tat, Rev and Nef expressing dendritic cells followed by treatment interruption
SD Allard, B De Keersmaecker, AL de Goede… - Clinical …, 2012 - Elsevier
In a phase I/IIa clinical trial, 17 HIV-1 infected patients, stable on cART, received 4
vaccinations with autologous dendritic cells electroporated with mRNA encoding Tat, Rev …
vaccinations with autologous dendritic cells electroporated with mRNA encoding Tat, Rev …
Concurrent measures of total and integrated HIV DNA monitor reservoirs and ongoing replication in eradication trials
AM Mexas, EH Graf, MJ Pace, JY Jianqing… - Aids, 2012 - journals.lww.com
Objectives: Interest in targeting HIV reservoirs is fueling trials that may decrease reservoir
size and/or induce viral replication. Therefore, we aimed to develop strategies to sensitively …
size and/or induce viral replication. Therefore, we aimed to develop strategies to sensitively …