Many, if not most, enzymes can promiscuously catalyze reactions, or act on substrates, other
than those for which they evolved. Here, we discuss the structural, mechanistic, and …

The divergence of new genes and proteins occurs through mutations that modulate protein
function. However, mutations are pleiotropic and can have different effects on organismal …

From reviews to the first edtion:" Bornscheuer and Kazlauskas have set out, and succeeded,
in producing a definitive manual on hydrolytic enzymes (especially lipases, esterases, and …

The past few years have seen significant advances in research related to the 'latent skills' of
enzymes—namely, their capacity to promiscuously catalyze reactions other than the ones …

Highlights•Screening efforts have revealed enzymes with over 100 promiscuous
activities.•High-throughput screening for promiscuous activities can be accomplished in …

Biocatalysis has expanded rapidly in the last decades with the discoveries of highly
stereoselective enzymes with broad substrate specificity. A new frontier for biocatalysis is …

Recent studies of moonlighting functions and catalytic promiscuity provide insights into the
structural and mechanistic bases of these phenomena. Moonlighting proteins that are …

Recent work has shed light on the abundance and diversity of d-amino acids in bacterial
extracellular/periplasmic molecules, bacterial cell culture, and bacteria-rich environments …

▪ Abstract The protein sequence and structure databases are now sufficiently representative
that strategies nature uses to evolve new catalytic functions can be identified. Groups of …

Abstract The 1, 4-naphthoquinones (1, 4-NQs) are a diverse group of natural products found
in every kingdom of life. Plants, including many horticultural species, collectively synthesize …