Exploring miRNA based approaches in cancer diagnostics and therapeutics

S Mishra, T Yadav, V Rani - Critical reviews in oncology/hematology, 2016 - Elsevier
MicroRNAs (miRNAs), a highly conserved class of tissue specific, small non-protein coding
RNAs maintain cell homeostasis by negative gene regulation. Proper controlling of miRNA …

MicroRNA-29 family, a crucial therapeutic target for fibrosis diseases

Y He, C Huang, X Lin, J Li - Biochimie, 2013 - Elsevier
MicroRNAs (miRNAs) are a class of approximately 20-nucleotides single-stranded
endogenous RNAs that regulate gene expression at the post-transcriptional level. miRNAs …

miRNA–transcription factor interactions: a combinatorial regulation of gene expression

S Arora, R Rana, A Chhabra, A Jaiswal… - Molecular genetics and …, 2013 - Springer
Developmental processes require a precise spatio-temporal regulation of gene expression
wherein a diverse set of transcription factors control the signalling pathways. MicroRNAs …

Diagnostic potential of plasmatic MicroRNA signatures in stable and unstable angina

Y D'Alessandra, MC Carena, L Spazzafumo… - PloS one, 2013 - journals.plos.org
Purpose We examined circulating miRNA expression profiles in plasma of patients with
coronary artery disease (CAD) vs. matched controls, with the aim of identifying novel …

MicroRNA-146a modulates TGF-beta1-induced hepatic stellate cell proliferation by targeting SMAD4

Y He, C Huang, X Sun, X Long, X Lv, J Li - Cellular signalling, 2012 - Elsevier
Activation of hepatic stellate cells (HSC) plays a pivotal role in the development of hepatic
fibrosis. Transforming growth factor-β1 (TGF-β1) is considered to be the main stimuli factor …

MicroRNAs regulate tight junction proteins and modulate epithelial/endothelial barrier functions

C Cichon, H Sabharwal, C Rüter, MA Schmidt - Tissue barriers, 2014 - Taylor & Francis
Tightly controlled epithelial and endothelial barriers are a prerequisite for life as these
barriers separate multicellular organisms from their environment and serve as first lines of …

Primary hepatocyte cultures for pharmaco-toxicological studies: at the busy crossroad of various anti-dedifferentiation strategies

J Fraczek, J Bolleyn, T Vanhaecke, V Rogiers… - Archives of …, 2013 - Springer
Continuously increasing understanding of the molecular triggers responsible for the onset of
diseases, paralleled by an equally dynamic evolution of chemical synthesis and screening …

Regulatory role of miRNAs in polyamine gene expression in the prefrontal cortex of depressed suicide completers

JP Lopez, LM Fiori, JA Gross, B Labonte… - International Journal …, 2014 - academic.oup.com
MicroRNAs (miRNAs) are small, non-coding RNA molecules that play an important role in
the post-transcriptional regulation of mRNA. These molecules have been the subject of …

Endothelial dysfunction in individuals born after fetal growth restriction: cardiovascular and renal consequences and preventive approaches

C Yzydorczyk, JB Armengaud, AC Peyter… - … origins of health and …, 2017 - cambridge.org
Individuals born after intrauterine growth restriction (IUGR) have an increased risk of
perinatal morbidity/mortality, and those who survive face long-term consequences such as …

The potential of microRNAs in liver fibrosis

Y He, C Huang, S Zhang, X Sun, X Long, J Li - Cellular signalling, 2012 - Elsevier
MicroRNAs (miRNAs) are a class of~ 22-nucleotides noncoding RNAs that regulate gene
expression by specifically binding with 3'-untranslated region (3'-UTR) of target gene …