Pyridazinone: an important element of pharmacophore possessing broad spectrum of activity

S Dubey, PA Bhosle - Medicinal Chemistry Research, 2015 - Springer
In the last few years, the pyridazine derivatives have been found to exhibit a wide range of
pharmacological activities. A large number of research articles and patents described them …

The effect of pyridazine compounds on the cardiovascular system

M Asif, A Singh, AA Siddiqui - Medicinal Chemistry Research, 2012 - Springer
Many natural as well as synthetic heterocylic compounds are known to have different
biological activities. The pyridazine moiety is an important structural feature of many …

Synthesis and analgesic and anti-inflammatory activities 6-substituted-3 (2H)-pyridazinone-2-acetyl-2-(p-substituted/nonsubstituted benzal) hydrazone derivatives

M Gökçe, S Utku, E Küpeli - European journal of medicinal chemistry, 2009 - Elsevier
In this study new 6-substituted-3 (2H)-pyridazinone-2-acetyl-2-(p-substituted benzal)
hydrazone V derivatives were synthesized as analgesic and anti-inflammatory agents. The …

Focusing on New Piperazinyl‐methyl‐3(2H)pyridazinone Based Derivatives: Design, Synthesis, Anticancer Activity and Computational Studies

İB Merde, GT Önel, S Akkoç, Z Karaköy… - …, 2023 - Wiley Online Library
Heterocyclics containing pyridazinone and piperazine structures are potential anticancer
agents in the treatment of cancer disease caused by increasing the number of abnormal …

Synthesis of Schiff and Mannich bases of isatin derivatives with 4-amino-4, 5-dihydro-1H-1, 2, 4-triazole-5-ones

O Bekircan, H Bektas - Molecules, 2008 - mdpi.com
Ethyl imidate hydrochlorides 1 were prepared by passing HCl gas through solutions of
substituted benzyl cyanides and absolute ethanol. Ethoxycarbonylhydrazones 2 were …

Zn Complex on Tryptophan-Functionalized MCM-41 as an Efficient and Promising Reusable Nanocatalyst in One-Pot Three-Component Synthesis of Amino Benzyl …

S Hamedimehr, K Ojaghi Aghbash… - ACS …, 2023 - ACS Publications
In this research, a Zn transition metallic complex on functionalized mesopore silica MCM-41
has been designed and utilized as an effective, recoverable, and thermally stable …

Pyridazinonderivate

D Dorsch, F Stieber, O Schadt, A Blaukat - 2014 - Google Patents
0* C (c1cccc (CC (C (C= C2)= O) I= C2c (cc2C= C) cc (*) c2N) c1)=* Chemical compound* C
(c1cccc (CC (C (C= C2)= O) I= C2c (cc2C= C) cc (*) c2N) c1)=* 0.000 description …

Antimicrobial pyridazines: synthesis, characterization, cytotoxicity, substrate promiscuity, and molecular docking

M Mustafa, YA Mostafa - Chemistry & Biodiversity, 2020 - Wiley Online Library
A facile and convenient synthesis of new pyridazines suitable for use as antimicrobial
agents was reported. The hydrazide intermediate was coupled with various benzaldehydes …

Derivatives of pyrrolo [3, 4-d] pyridazinone, a new class of analgesic agents

W Malinka, A Redzicka, M Jastrzębska–Więsek… - European journal of …, 2011 - Elsevier
A series of N2-{2-[4-aryl (benzyl)-1-piperazinyl (piperidinyl)] ethyl} pyrrolo [3, 4-d]
pyridazinones 4 and related derivatives 5 were synthesized as potential analgesic agents …

General study of pyridazine compounds against cyclooxygenase enzyme and their relation with analgesic, anti-inflammatory and anti-arthritic activities

M Asif - Chronicles of Young Scientists, 2010 - go.gale.com
There is increased focus on developed non-steroidal anti-inflammatory drugs (NSAIDs)
containing a pyridazine nucleus. The NSAIDs are one of the most commonly used …