Changes in lifestyle induce an increase in patients with hyperuricemia (HUA), leading to
gout, gouty arthritis, renal damage, and cardiovascular injury. There is a strong inflammatory …

Metabolic switches are a crucial hallmark of cellular development and regeneration. In
response to changes in their environment or physiological state, cells undergo coordinated …

Bone and cartilage tissue play multiple roles in the organism, including kinematic support,
protection of organs, and hematopoiesis. Bone and, above all, cartilaginous tissues present …

Approaches to regenerating bone often rely on integrating biomaterials and biological
signals in the form of cells or cytokines. However, from a translational point of view, these …

Nanotechnology‐based approaches are promising for the treatment of musculoskeletal
(MSK) disorders, which present significant clinical burdens and challenges, but their clinical …

Non-healing bone defects are a pressing public health concern accounting for one main
cause for decreased life expectancy and quality. An aging population accompanied with …

This review examines the possible role of mitochondria in maintaining calcium and
phosphate ion homeostasis and participating in the mineralization of bone, cartilage and …

The role of osteoimmunomodulation in orthopedic biomaterials has been demonstrated to
be crucial in the regulation of bone repair and regeneration. Macrophages, the primary …

Imbalanced osteogenic cell-mediated bone gain and osteoclastic remodeling accelerates
the development of osteoporosis, which is the leading risk factor of disability in the elderly …

Approximately half of bone fractures that do not heal properly (non-union) can be accounted
to insufficient angiogenesis. The processes of angiogenesis and osteogenesis are …