Intersection of pathological tau and microglia at the synapse

T Vogels, AN Murgoci, T Hromádka - Acta neuropathologica …, 2019 - Springer
Tauopathies are a heterogenous class of diseases characterized by cellular accumulation of
aggregated tau and include diseases such as Alzheimer's disease (AD), progressive …

Peptide-based vaccines for neurodegenerative diseases: Recent endeavors and future perspectives

V Vassilakopoulou, CE Karachaliou, A Evangelou… - Vaccines, 2021 - mdpi.com
The development of peptide-based vaccines for treating human neurodegenerative
diseases has been the eventual aim of many research endeavors, although no active …

Physiological expression of mutated TAU impaired astrocyte activity and exacerbates β-amyloid pathology in 5xFAD mice

D Farfara, M Sooliman, L Avrahami, TG Royal… - Journal of …, 2023 - Springer
Background Alzheimer's disease (AD) is the leading cause of dementia in the world. The
pathology of AD is affiliated with the elevation of both tau (τ) and β-amyloid (Aβ) pathologies …

Current peptide vaccine and immunotherapy approaches against Alzheimer's disease

CMT Parrocha, JS Nowick - Peptide Science, 2023 - Wiley Online Library
Peptide vaccines and immunotherapies against aggregating proteins involved in the
pathogenesis and progression of Alzheimer's disease (AD)—the β‐amyloid peptide (Aβ) …

Brain targeting of 9c, 11t-Conjugated Linoleic Acid, a natural calpain inhibitor, preserves memory and reduces Aβ and P25 accumulation in 5XFAD mice

O Binyamin, K Nitzan, K Frid, Y Ungar, H Rosenmann… - Scientific reports, 2019 - nature.com
Deregulation of Cyclin-dependent kinase 5 (CDK5) by binding to the activated calpain
product p25, is associated with the onset of neurodegenerative diseases, such as …

[HTML][HTML] Active immunization with tau epitope in a mouse model of tauopathy induced strong antibody response together with improvement in short memory and …

A Joly-Amado, H Davtyan, K Serraneau, P Jules… - Neurobiology of …, 2020 - Elsevier
Abnormal tau hyperphosphorylation and its aggregation into neurofibrillary tangles are a
hallmark of tauopathies, neurodegenerative disorders that include Alzheimer's disease (AD) …

Both amyloid-β peptide and tau protein are affected by an anti-amyloid-β antibody fragment in elderly 3xTg-AD mice

AR Roda, L Montoliu-Gaya, G Serra-Mir… - International journal of …, 2020 - mdpi.com
Alzheimer's disease (AD) is the most common dementia worldwide. According to the
amyloid hypothesis, the early accumulation of the Aβ-peptide triggers tau phosphorylation …

Peptide interference with APP and tau association: relevance to Alzheimer's disease amelioration

R Maron, G Armony, M Tsoory, M Wilchek… - International journal of …, 2020 - mdpi.com
The two major proteins involved in Alzheimer's disease (AD) are the amyloid precursor
protein (APP) and Tau. Here, we demonstrate that these two proteins can bind to each other …

The Beneficial Effect of Mitochondrial Transfer Therapy in 5XFAD Mice via Liver–Serum–Brain Response

S Sweetat, K Nitzan, N Suissa, Y Haimovich… - Cells, 2023 - mdpi.com
We recently reported the benefit of the IV transferring of active exogenous mitochondria in a
short-term pharmacological AD (Alzheimer's disease) model. We have now explored the …

Complicaciones centrales en un modelo murino de enfermedad de alzheimer y diabetes mellitus: papel de la liraglutida

MJ Carranza-Naval - 2022 - rodin.uca.es
La enfermedad de Alzheimer (EA) es la causa más común de demencia. Se caracteriza
neuropatológicamente por el depósito del péptido β-amiloide (βA), la presencia de ovillos …