The E3 ubiquitin-ligase Bmi1/Ring1A controls the proteasomal degradation of Top2α cleavage complex–a potentially new drug target
I Alchanati, C Teicher, G Cohen, V Shemesh, HM Barr… - PloS one, 2009 - journals.plos.org
Background The topoisomerases Top1, Top2α and Top2β are important molecular targets
for antitumor drugs, which specifically poison Top1 or Top2 isomers. While it was previously …
for antitumor drugs, which specifically poison Top1 or Top2 isomers. While it was previously …
Understanding the role of the Josephin domain in the PolyUb binding and cleavage properties of ataxin-3
Ataxin-3, the disease protein in the neurodegenerative disorder Spinocerebellar Ataxia Type
3 or Machado Joseph disease, is a cysteine protease implicated in the ubiquitin proteasome …
3 or Machado Joseph disease, is a cysteine protease implicated in the ubiquitin proteasome …
Perturbing the Ubiquitin Pathway Reveals How Mitosis Is Hijacked to Denucleate and Regulate Cell Proliferation and Differentiation In Vivo
A Caceres, F Shang, E Wawrousek, Q Liu, O Avidan… - PLoS …, 2010 - journals.plos.org
Background The eye lens presents a unique opportunity to explore roles for specific
molecules in cell proliferation, differentiation and development because cells remain in …
molecules in cell proliferation, differentiation and development because cells remain in …