Purpose Intestinal mucositis and diarrhea are common manifestations of anticancer
regimens that include irinotecan, 5-fluorouracil (5-FU), and other cytotoxic drugs. These side …

The intestinal tract is the shared locus of intestinal epithelial cells, immune cells, nutrient
digestion and absorption, and microbial survival. The gut in animals faces continuous …

To investigate mechanisms by which thymoquinone (TQ) can prevent methotrexate‐(MTX‐)
induced hepatorenal toxicity, TQ (10 mg/kg) was administered orally for 10 days. In …

As a widely used anticancer and immunosuppressive agent, methotrexate (MTX) can induce
multiple adverse drug reactions (ADRs), such as gastrointestinal toxicity, the mechanisms …

Although methotrexate is widely used in clinics as an anticancer agent, it's utility is limited by
its gastrointestinal toxicity, the mechanism of which is unclear. The role of NFκB …

Methotrexate (MTX) is a well-known and widely used cytotoxic chemotherapeutic agent.
However, intestinal mucosa damage is a serious adverse effect of MTX. Taurine (TUR) is a …

Methotrexate (MTX), a chemotherapeutic and immunosuppressant drug, is generally well-
tolerated by most patients. However, its cytotoxic nature contributes to life-threatening side …

Parkinson's disease (PD) is a widespread neurodegenerative condition affecting millions
globally. This investigation centered on the gut-brain axis in a rotenone-induced PD rat …

Fluorouracil (5-FU)-induced intestinal mucositis (IM) is one of the most common oncological
problem. It involves serious clinical consequences such as diarrhea, erythematous lesions …

Etoposide is a semi-synthetic compound derived from the plant podophyllum pelltatum and
are antineoplastic agents long been used for treatment of human malignancies. The present …