Small Molecule Screen Identifies Non-catalytic USP3 Chemical Handle
MK Mann, E Wolf, M Silva, HA Kwak, B Wilson… - ACS …, 2023 - ACS Publications
Zinc-finger ubiquitin-binding domains (ZnF-UBDs) are noncatalytic domains mostly found in
deubiquitylases (DUBs) such as USP3. They represent an underexplored opportunity for the …
deubiquitylases (DUBs) such as USP3. They represent an underexplored opportunity for the …
Selective molecular inhibition of the HDAC6 ZnF-UBP binding domain impairs multiple myeloma cell proliferation
R Rincon, IF Coira, A Richieu, F Attana, M Urwyler… - bioRxiv, 2024 - biorxiv.org
Multiple myeloma is a plasma cell malignancy with poor prognosis despite the recent
development of new therapeutic options. Histone deacetylase 6 (HDAC6) is overexpressed …
development of new therapeutic options. Histone deacetylase 6 (HDAC6) is overexpressed …
Conversion of Small-Molecule Inhibitors into Heterobifunctional Compounds in the Discovery of Novel Chemotherapeutics
A Chan - 2023 - archive.hshsl.umaryland.edu
Heterobifunctional polypharmacologic agents are compounds that have individual
pharmacophores for at least two separate biological targets. Our work spans two distinct sets …
pharmacophores for at least two separate biological targets. Our work spans two distinct sets …