Tegument assembly and secondary envelopment of alphaherpesviruses
Alphaherpesviruses like herpes simplex virus are large DNA viruses characterized by their
ability to establish lifelong latent infection in neurons. As for all herpesviruses …
ability to establish lifelong latent infection in neurons. As for all herpesviruses …
HSV-1 cytoplasmic envelopment and egress
I Ahmad, DW Wilson - International journal of molecular sciences, 2020 - mdpi.com
Herpes simplex virus type 1 (HSV-1) is a structurally complex enveloped dsDNA virus that
has evolved to replicate in human neurons and epithelia. Viral gene expression, DNA …
has evolved to replicate in human neurons and epithelia. Viral gene expression, DNA …
Structure of the herpes simplex virus 1 capsid with associated tegument protein complexes
INTRODUCTION Since Hippocrates first described the cutaneous spreading of herpes
simplex lesions, many other diseases—chickenpox, infectious mononucleosis …
simplex lesions, many other diseases—chickenpox, infectious mononucleosis …
Cytosolic herpes simplex virus capsids not only require binding inner tegument protein pUL36 but also pUL37 for active transport prior to secondary envelopment
M Sandbaumhüter, K Döhner, J Schipke… - Cellular …, 2013 - Wiley Online Library
As the inner tegument proteins pUL36 and pUL37 of alphaherpesviruses may contribute to
efficient intracellular transport of viral particles, we investigated their role in cytosolic capsid …
efficient intracellular transport of viral particles, we investigated their role in cytosolic capsid …
Identification and classification of papain-like cysteine proteinases
F Ozhelvaci, K Steczkiewicz - Journal of Biological Chemistry, 2023 - ASBMB
Papain-like cysteine peptidases form a big and highly diverse superfamily of proteins
involved in many important biological functions, such as protein turnover, deubiquitination …
involved in many important biological functions, such as protein turnover, deubiquitination …
Role of tegument proteins in herpesvirus assembly and egress
Morphogenesis and maturation of viral particles is an essential step of viral replication. An
infectious herpesviral particle has a multilayered architecture, and contains a large DNA …
infectious herpesviral particle has a multilayered architecture, and contains a large DNA …
The C terminus of the large tegument protein pUL36 contains multiple capsid binding sites that function differently during assembly and cell entry of herpes simplex …
J Schipke, A Pohlmann, R Diestel, A Binz… - Journal of …, 2012 - Am Soc Microbiol
The largest tegument protein of herpes simplex virus type 1 (HSV1), pUL36, is a multivalent
cross-linker between the viral capsids and the tegument and associated membrane proteins …
cross-linker between the viral capsids and the tegument and associated membrane proteins …
The role of VP16 in the life cycle of alphaherpesviruses
D Fan, M Wang, A Cheng, R Jia, Q Yang… - Frontiers in …, 2020 - frontiersin.org
The protein encoded by the UL48 gene of alphaherpesviruses is named VP16 or alpha-
gene-transactivating factor (α-TIF). In the early stage of viral replication, VP16 is an important …
gene-transactivating factor (α-TIF). In the early stage of viral replication, VP16 is an important …
A Nuclear localization signal in herpesvirus protein VP1-2 is essential for infection via capsid routing to the nuclear pore
F Abaitua, M Hollinshead, M Bolstad… - Journal of …, 2012 - Am Soc Microbiol
To initiate infection, herpesviruses must navigate to and transport their genomes across the
nuclear pore. VP1-2 is a large structural protein of the virion that is conserved in all …
nuclear pore. VP1-2 is a large structural protein of the virion that is conserved in all …
The incredible bulk: Human cytomegalovirus tegument architectures uncovered by AI-empowered cryo-EM
The compartmentalization of eukaryotic cells presents considerable challenges to the
herpesvirus life cycle. The herpesvirus tegument, a bulky proteinaceous aggregate …
herpesvirus life cycle. The herpesvirus tegument, a bulky proteinaceous aggregate …