Oleuropein counteracts both the proliferation and migration of intra-and extragonadal seminoma cells

S Bossio, A Perri, R Malivindi, F Giordano, V Rago… - Nutrients, 2022 - mdpi.com
Recent and growing literature has reported that oleuropein (OLE), the main polyphenol in
olive leaf extract, inhibits tumor cell proliferation and reduces the invasiveness properties of …

Pituitary tumor‑transforming gene 1 regulates the senescence and apoptosis of oral squamous cell carcinoma in a p21‑dependent DNA damage response manner

S Park, S Kim, MY Kim, SS Lee… - Oncology …, 2024 - spandidos-publications.com
Pituitary tumor-transforming gene 1 (PTTG1), also known as securin, is a proto-oncogene
involved in the development of various cancers by promoting cell proliferation and mobility …

PTTG1 enhances oncolytic adenovirus 5 entry into pancreatic adenocarcinoma cells by increasing CXADR expression

L Long, J Gao, R Zhang - Viruses, 2023 - mdpi.com
Pituitary tumor-transforming gene 1 (PTTG1) is overexpressed in various types of tumors
and functions as an oncogene; it could also be a potential target in tumor therapy …

PTTG1/ZEB1 axis regulates E-cadherin expression in human seminoma

E Teveroni, F Di Nicuolo, E Vergani, G Bianchetti… - Cancers, 2022 - mdpi.com
Simple Summary Seminoma represents one of the most common neoplasms in Caucasian
males between 15 and 40 years old. The molecular pathways underlying its clinical …

[HTML][HTML] Multi-omics Analysis of the oncogenic value of pituitary tumor-transforming gene 1 (PTTG1) in human cancers

L Wang, X Liu - Frontiers in Bioscience-Landmark, 2024 - imrpress.com
Background: The pituitary tumor-transforming gene 1 (PTTG1), also recognized as securin,
plays a crucial role in diverse biological processes, such as restraining sister chromatid …

SPTBN1 Mediates the Cytoplasmic Constraint of PTTG1, Impairing Its Oncogenic Activity in Human Seminoma

E Teveroni, F Di Nicuolo, E Vergani, A Oliva… - International Journal of …, 2023 - mdpi.com
Seminoma is the most common testicular cancer. Pituitary tumor-transforming gene 1
(PTTG1) is a securin showing oncogenic activity in several tumors. We previously …

Molecular feature-based classification of retroperitoneal liposarcoma: a prospective cohort study

M Xiao, X Li, F Bu, S Ma, X Yang, J Chen, Y Zhao… - MedRxiv, 2024 - medrxiv.org
Background: Retroperitoneal liposarcoma (RPLS) is a critical malignant disease with
various clinical outcomes. However, the molecular heterogeneity of RPLS was poorly …

Elevated PTTG1 predicts poor prognosis in kidney renal clear cell carcinoma and correlates with immunity

X Zhang, H Ji, Y Huang, B Zhu, Q Xing - Heliyon, 2023 - cell.com
Background PTTG1 has been reported to be linked with the prognosis and progression of
various cancers, including kidney renal clear cell carcinoma (KIRC). In this article, we mainly …

Expression of CD44 is associated with aggressiveness in seminomas

VT Labropoulou, D Manou, P Ravazoula… - Molecular Biology …, 2024 - Springer
Background Testicular germ cell tumors (TGCTs) exhibit diverse biological and pathological
features and are divided in two main types, seminomas and nonseminomatous germ cell …

Pituitary tumor transforming gene 1 promotes proliferation and malignant phenotype in osteosarcoma via NF-κB signaling

X Hu, F Yang, H Mei - Journal of Orthopaedic Science, 2024 - Elsevier
Background Pituitary tumor transforming gene (PTTG) is an oncogene reported to be
actively promotes tumorigenesis in multiple tumors. Osteosarcoma (OS) is the most common …