[HTML][HTML] The hidden RNA code: implications of the RNA epitranscriptome in the context of viral infections

DR Ribeiro, A Nunes, D Ribeiro, AR Soares - Frontiers in Genetics, 2023 - frontiersin.org
Emerging evidence highlights the multifaceted roles of the RNA epitranscriptome during
viral infections. By modulating the modification landscape of viral and host RNAs, viruses …

[HTML][HTML] The regulation of antiviral innate immunity through non-m6A RNA modifications

S Shen, LS Zhang - Frontiers in Immunology, 2023 - frontiersin.org
The post-transcriptional RNA modifications impact the dynamic regulation of gene
expression in diverse biological and physiological processes. Host RNA modifications play …

[HTML][HTML] Transcriptomic Signatures of Zika Virus Infection in Patients and a Cell Culture Model

G Berglund, CD Lennon, P Badu, JA Berglund… - Microorganisms, 2024 - mdpi.com
Zika virus (ZIKV), a re-emerging flavivirus, is associated with devasting developmental and
neurological disease outcomes particularly in infants infected in utero. Towards …

The landscape of differential splicing and transcript alternations in severe COVID‐19 infection

SB Mukherjee, S Mukherjee, R Detroja… - The FEBS …, 2023 - Wiley Online Library
Viral infections can modulate the widespread alternations of cellular splicing, favouring viral
replication within the host cells by overcoming host immune responses. However, how …

[HTML][HTML] COVIDanno, COVID-19 annotation in human

Y Feng, M Yang, Z Fan, W Zhao, P Kim… - Frontiers in …, 2023 - frontiersin.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiologic agent of
coronavirus disease 19 (COVID-19), has caused a global health crisis. Despite ongoing …

[HTML][HTML] CASA: a comprehensive database resource for the COVID-19 Alternative Splicing Atlas

Y Chen, G Wang, J Li, L Xia, L Zhu, W Li, Q Luo… - Journal of Translational …, 2022 - Springer
Background As a key process in transcriptional regulatory mechanisms, alternative splicing
(AS) plays a crucial role in maintaining the diversity of RNA and protein expression, and …

All differential on the splicing front: Host alternative splicing alters the landscape of virus-host conflict

JT Mann, BA Riley, SF Baker - Seminars in Cell & Developmental Biology, 2023 - Elsevier
Alternative RNA splicing is a co-transcriptional process that richly increases proteome
diversity, and is dynamically regulated based on cell species, lineage, and activation state …

[HTML][HTML] Zika virus infection in a cell culture model reflects the transcriptomic signatures in patients

G Berglund, CD Lennon, P Badu, JA Berglund… - bioRxiv, 2024 - ncbi.nlm.nih.gov
Zika virus (ZIKV), a re-emerging flavivirus, is associated with devasting developmental and
neurological disease outcomes particularly in infants infected in utero. Towards …

The leader RNA of SARS-CoV-2 sequesters polypyrimidine tract binding protein (PTBP1) and influences pre-mRNA splicing in infected cells

NH Altina, DG Maranon, JR Anderson, MK Donaldson… - Virology, 2024 - Elsevier
The large amount of viral RNA produced during infections has the potential to interact with
and effectively sequester cellular RNA binding proteins, thereby influencing aspects of post …

An algorithmic framework for isoform-specific functional analysis

G Karlebach, L Carmody, JC Sundaramurthi… - Biorxiv, 2022 - biorxiv.org
Gene Ontology (GO) overrepresentation analysis characterizes the biological mechanisms
common to sets of differentially expressed genes identified by high-throughput experiments …