Cancers represent complex ecosystems comprising tumor cells and a multitude of non-
cancerous cells, embedded in an altered extracellular matrix. The tumor microenvironment …

The immense diversity of extracellular matrix (ECM) proteins confers distinct biochemical
and biophysical properties that influence cell phenotype. The ECM is highly dynamic as it is …

Simple Summary Cancer metastasis is often associated with a dismal prognosis for the
patient. It is, therefore, crucial to understand the mechanisms behind the cascade of events …

Metastasis is the most complex and deadly event. Tumor-stromal interface is a place where
invasion of tumor cells in the form of single-cell or collective migration occurs, with the latter …

The cell microenvironment has emerged as a key determinant of cell behavior and function
in development, physiology, and pathophysiology. The extracellular matrix (ECM) within the …

The extracellular matrix is perturbed in tumors. The tumor matrix promotes the growth,
survival, and invasion of the cancer and modifies fibroblast and immune cell behavior to …

Tumors are influenced by the mechanical properties of their microenvironment. Using
patient samples and atomic force microscopy, we found that tissue stiffness is higher in liver …

The pulmonary extracellular matrix (ECM) determines the tissue architecture of the lung, and
provides mechanical stability and elastic recoil, which are essential for physiological lung …

Metastasis is a multistep process in which tumor extracellular matrix (ECM) and cancer cell
cytoskeleton interactions are pivotal. ECM is connected, through integrins, to the cell's …

Mechanical hallmarks of fibrotic microenvironments are both outcomes and causes of
fibrosis progression. Understanding how cells sense and transmit mechanical cues in the …