Alterations in the composition or function of the gut microbiota are associated with the
etiology of human diseases. Drug-microbiota interactions can affect drug bioavailability …

In the half-century since its discovery, nuclear magnetic resonance (NMR) has become the
single most powerful form of spectroscopy in both chemistry and structural biology. The …

Due to its immunomodulatory effects and the limitation in the radiological damage
progression, disease-modifying antirheumatic drugs (DMARDs) work as first-line rheumatoid …

Opportunistic infections are known to cause morbidity and mortality in immunocompromised
individuals. In addition, serious infections due to several parasites are also known to affect …

Introduction Our understanding of the mechanism of action of bioactive small molecules
contributes to the research and development of new medical drugs, as well as elucidating …

Background Methotrexate (MTX) is an agent used in chemotherapy of tumors and
autoimmune disease including rheumatoid arthritis (RA). In addition, MTX has some anti …

The isolation of both specific and nonspecific binding proteins on affinity matrices bearing
bioactive compounds hinders the identification of drug cellular targets. Although solid-phase …

Methotrexate is a widely used anti-metabolite in cancer chemotherapy. A series of
halogenated drugs is designed from Methotrexate to assess their interactions with human …

NMR methods for the study of motion in proteins continue to improve, and a number of
studies of protein–ligand complexes relevant to drug design have been reported over the …

Unique capabilities are offered by NMR spectroscopy for probing specific interactions of
enzymes with substrates and substrate analogues, for characterizing the multiple …