Metabolic reprogramming and epigenetic modifications are hallmarks of cancer cells. In
cancer cells, metabolic pathway activity varies during tumorigenesis and cancer …

Reversible, spatial, and temporal regulation of metabolic reprogramming and epigenetic
homeostasis are prominent hallmarks of carcinogenesis. Cancer cells reprogram their …

Epigenetic modifiers frequently harbor loss-of-function mutations in lung cancer, but their
tumor-suppressive roles are poorly characterized. Histone methyltransferase KMT2D (a …

Lung squamous cell carcinoma (LUSC) represents a major subtype of lung cancer with
limited treatment options. KMT2D is one of the most frequently mutated genes in LUSC (> …

Digestive cancers are the leading cause of cancer-related death worldwide and have high
risks of morbidity and mortality. Histone methylation, which is mediated mainly by lysine …

Glycolysis plays a crucial role in reprogramming the metastatic tumor microenvironment. A
series of lncRNAs have been identified to function as oncogenic molecules by regulating …

Background Resistance to cell death, a protective mechanism for removing damaged cells,
is a “Hallmark of Cancer” that is essential for cancer progression. Increasing attention to …

Surgical resection, when combined with chemotherapy, has been shown to significantly
improve the survival rate of patients with pancreatic ductal adenocarcinoma (PDAC) …

Metabolic and epigenetic reprogramming are characteristics of cancer cells that, in many
cases, are linked. Oncogenic signaling, diet, and tumor microenvironment each influence …

Epigenetic mechanisms are central to understanding the molecular basis underlying
tumorigenesis. Aberrations in epigenetic modifiers alter epigenomic landscapes and play a …