Increasing evidence foresees the secretome of neural stem cells (NSCs) to confer
superimposable beneficial properties as exogenous NSC transplants in experimental …

Voltage-gated sodium channels (Navs) are critical determinants of cellular excitability.
These ion channels exist as large heteromultimeric structures and their activity is tightly …

Among the FGF proteins, the least characterized superfamily is the group of fibroblast growth
factor homologous factors (FHFs). To date, the main role of FHFs has been primarily seen in …

Introduction Luminescence-based technologies, specifically bioluminescence and
chemiluminescence, are powerful tools with extensive use in drug discovery. Production of …

Artificial Intelligence (AI) has made much progress, but the existing paradigm for AI is still
basically pattern recognition based on a human-handcrafted representation. An AI paradigm …

Background Excess tumor necrosis factor (TNF) is implicated in the pathogenesis of
hyperinflammatory experimental cerebral malaria (eCM), including gliosis, increased levels …

The voltage-gated Na+ (Nav) channel is a primary molecular determinant of the initiation
and propagation of the action potential. Despite the central role of the pore-forming α subunit …

Background Protein interactions between voltage-gated sodium (Nav) channels and
accessory proteins play an essential role in neuronal firing and plasticity. However, a …

The voltage‐gated sodium (Nav) channel complex is comprised of pore‐forming α subunits
(Nav1. 1–1.9) and accessory regulatory proteins such as the intracellular fibroblast growth …

The voltage-gated Na+ (Nav) channel is the molecular determinant of excitability. Disruption
of protein–protein interactions (PPIs) between Nav1. 6 and fibroblast growth factor 14 …