Leukocytes can completely reorganize their cytoskeletal architecture within minutes. This
structural plasticity, which facilitates their migration and communicative function, also …

Integrins are cell adhesion molecules that mediate cell-cell, cell–extracellular matrix, and
cell-pathogen interactions. They play critical roles for the immune system in leukocyte …

The burgeoning field of leukocyte trafficking has created new and exciting opportunities in
the clinic. Trafficking signals are being defined that finely control the movement of distinct …

Complement receptors (CR) 3 and 4 belong to the family of beta-2 (CD18) integrins. CR3
and CR4 are often co-expressed in the myeloid subsets of leukocytes, but they are also …

Rodent-borne hantaviruses are emerging human pathogens that cause severe human
disease. The underlying mechanisms are not well understood, as hantaviruses replicate in …

This review article describes the use of immune cells as potential candidates to deliver anti-
cancer drugs deep within the tumor microenvironment. First, the rationale of using drug …

We report the structure of an integrin with an αI domain, αXβ2, the complement receptor type
4. It was earlier expected that a fixed orientation between the αI domain and the β‐propeller …

Leucocytes are highly motile cells. Their ability to migrate into tissues and organs is
dependent on cell adhesion molecules. The integrins are a family of heterodimeric …

The transmembrane peptidase prostate-specific membrane antigen (PSMA) is universally
upregulated in the vasculature of solid tumors, but its functional role in tumor angiogenesis …

Biomaterial implants are an established part of medical practice, encompassing a broad
range of devices that widely differ in function and structural composition. However, one …