Alzheimer's disease (AD) is the most common form of dementia, characterized by
progressive cognitive impairment and neurodegeneration. Extensive clinical and genomic …

Understanding cellular heterogeneity is the holy grail of biology and medicine. Cells
harboring identical genomes show a wide variety of behaviors in multicellular organisms …

Gene-expression bimodality, as a potential mechanism generating phenotypic cell diversity,
can enhance the survival of cells in a fluctuating environment. Previous studies have shown …

Single-cell multimodal omics (scMulti-omics) technologies have made it possible to trace
cellular lineages during differentiation and to identify new cell types in heterogeneous cell …

Abstract Background Ovarian cancer (OvCa) is one of the most fatal cancers among females
in the world. With growing numbers of individuals diagnosed with OvCa ending in deaths, it …

Due to the lack of symptoms and detection biomarkers at the early stage, most patients with
ovarian cancer (OC) are diagnosed at an advanced stage and often face chemoresistance …

Colorectal cancer (CRC) is one of the most common tumors worldwide and is associated
with high mortality. Here we performed bioinformatics analysis, which we validated using …

Single-cell RNA-sequencing (scRNA-seq) is a recent high-throughput technique that can
measure gene expression, reveal cell heterogeneity, rare and complex cell populations, and …

2 colorectal cancer (CRC) remains mostly unknown. This study was aimed 23 at exploring
the specific role of lncRNA EGOT in CRC. Data from this 24 study revealed that EGOT …

Identifying precise molecular subtypes attributable to specific stages of localized prostate
cancer has proven difficult due to high levels of heterogeneity. Bulk assays represent a …