Flavonols as potential antiviral drugs targeting SARS-CoV-2 proteases (3CLpro and PLpro), spike protein, RNA-dependent RNA polymerase (RdRp) and angiotensin …

C Mouffouk, S Mouffouk, S Mouffouk… - European journal of …, 2021 - Elsevier
The novel coronavirus outbreak (COVID-19) caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) represents the actual greatest global public health crisis. The …

Bisphenol A (BPA) leading to obesity and cardiovascular complications: a compilation of current in vivo study

R Naomi, MD Yazid, H Bahari, YY Keong… - International journal of …, 2022 - mdpi.com
BPA is one of the most common endocrine disruptors that is widely being manufactured
daily nationwide. Although scientific evidence supports claims of negative effects of BPA on …

Therapeutic potential of quercetin as an antiatherosclerotic agent in atherosclerotic cardiovascular disease: a review

Q Deng, XX Li, Y Fang, X Chen… - … and Alternative Medicine, 2020 - Wiley Online Library
Atherosclerotic cardiovascular disease (ASCVD) is one of the diseases with the highest
morbidity and mortality globally. It causes a huge burden on families and caregivers and …

Oxidative stress in bisphenol AF-induced cardiotoxicity in zebrafish and the protective role of N-acetyl N-cysteine

J Gu, H Wang, L Zhou, D Fan, L Shi, G Ji… - Science of the Total …, 2020 - Elsevier
Research has shown that there is a relationship between bisphenol A (BPA) exposure and
the incidence of cardiovascular diseases. However, the effect of bisphenol AF (BPAF), a …

Paeoniflorin Ameliorates Skeletal Muscle Atrophy in Chronic Kidney Disease via AMPK/SIRT1/PGC-1α-Mediated Oxidative Stress and Mitochondrial Dysfunction

Q Li, J Wu, J Huang, R Hu, H You, L Liu… - Frontiers in …, 2022 - frontiersin.org
Skeletal muscle atrophy is a common and serious complication of chronic kidney disease
(CKD). Oxidative stress and mitochondrial dysfunction are involved in the pathogenesis of …

Mitochondrial Modulators: the defender

E Makinde, L Ma, GD Mellick, Y Feng - Biomolecules, 2023 - mdpi.com
Mitochondria are widely considered the “power hub” of the cell because of their pivotal roles
in energy metabolism and oxidative phosphorylation. However, beyond the production of …

Neuroprotective effects of quercetin in pediatric neurological diseases

L Alvarez-Arellano, M Salazar-García, JC Corona - Molecules, 2020 - mdpi.com
Oxidative stress is a crucial event underlying several pediatric neurological diseases, such
as the central nervous system (CNS) tumors, autism spectrum disorder (ASD) and attention …

Protective effect of quercetin against 5-fluorouracil-induced cardiac impairments through activating Nrf2 and inhibiting NF-κB and caspase-3 activities

MS Lokman, HA Althagafi, F Alharthi… - … Science and Pollution …, 2023 - Springer
Fluorouracil (5-FU) is a chemotherapy used to treat many types of cancer. Cardiotoxicity is
one of the common drawbacks of 5-FU therapy. Quercetin (Qu) is a bioflavonoid with striking …

The Protective Effects of Syringic Acid on Bisphenol A–Induced Neurotoxicity Possibly Through AMPK/PGC-1α/Fndc5 and CREB/BDNF Signaling Pathways

B Helli, SP Navabi, SA Hosseini, A Sabahi… - Molecular …, 2024 - Springer
Bisphenol A (BPA), an endocrine disruptor, is commonly used to produce epoxy resins and
polycarbonate plastics. Continuous exposure to BPA may contribute to the development of …

Evaluating endocrine disrupting chemicals: A perspective on the novel assessments in CLARITY‐BPA

KL Howdeshell, BEJ Beverly, RB Blain… - Birth Defects …, 2023 - Wiley Online Library
Abstract Background The Consortium Linking Academic and Regulatory Insights on
Bisphenol A Toxicity (CLARITY‐BPA) was a collaborative research effort to better link …