Immunogenetics of type 1 diabetes mellitus
MP Morran, A Vonberg, A Khadra… - Molecular aspects of …, 2015 - Elsevier
Type 1 diabetes mellitus (T1DM) is an autoimmune disease arising through a complex
interaction of both genetic and immunologic factors. Similar to the majority of autoimmune …
interaction of both genetic and immunologic factors. Similar to the majority of autoimmune …
Immune mechanisms in type 1 diabetes
M Wållberg, A Cooke - Trends in immunology, 2013 - cell.com
There are three prerequisites for development of the autoimmune disease type 1 diabetes
(T1D). First, β cell-reactive T cells need to be activated; second, the response needs to be …
(T1D). First, β cell-reactive T cells need to be activated; second, the response needs to be …
Inflammation-induced IgA+ cells dismantle anti-liver cancer immunity
The role of adaptive immunity in early cancer development is controversial. Here we show
that chronic inflammation and fibrosis in humans and mice with non-alcoholic fatty liver …
that chronic inflammation and fibrosis in humans and mice with non-alcoholic fatty liver …
Gender bias in autoimmunity is influenced by microbiota
L Yurkovetskiy, M Burrows, AA Khan, L Graham… - Immunity, 2013 - cell.com
Gender bias and the role of sex hormones in autoimmune diseases are well established. In
specific pathogen-free nonobese diabetic (NOD) mice, females have 1.3–4.4 times higher …
specific pathogen-free nonobese diabetic (NOD) mice, females have 1.3–4.4 times higher …
CD11c-expressing B cells are located at the T cell/B cell border in spleen and are potent APCs
AV Rubtsov, K Rubtsova, JW Kappler… - The Journal of …, 2015 - journals.aai.org
In addition to the secretion of Ag-specific Abs, B cells may play an important role in the
generation of immune responses by efficiently presenting Ag to T cells. We and other …
generation of immune responses by efficiently presenting Ag to T cells. We and other …
[HTML][HTML] Single-cell RNA sequencing of murine islets shows high cellular complexity at all stages of autoimmune diabetes
Tissue-specific autoimmune diseases are driven by activation of diverse immune cells in the
target organs. However, the molecular signatures of immune cell populations over time in an …
target organs. However, the molecular signatures of immune cell populations over time in an …
B cells in type 1 diabetes mellitus and diabetic kidney disease
MJ Smith, KM Simmons, JC Cambier - Nature Reviews Nephrology, 2017 - nature.com
Type 1 diabetes mellitus (T1DM) is an autoimmune disorder that affects an estimated 30
million people worldwide. It is characterized by the destruction of pancreatic β cells by the …
million people worldwide. It is characterized by the destruction of pancreatic β cells by the …
The immunology of type 1 diabetes
KC Herold, T Delong, AL Perdigoto, N Biru… - Nature Reviews …, 2024 - nature.com
Following the seminal discovery of insulin a century ago, treatment of individuals with type 1
diabetes (T1D) has been largely restricted to efforts to monitor and treat metabolic glucose …
diabetes (T1D) has been largely restricted to efforts to monitor and treat metabolic glucose …
B cells in autoimmune diseases
CS Hampe - Scientifica, 2012 - Wiley Online Library
The role of B cells in autoimmune diseases involves different cellular functions, including the
well‐established secretion of autoantibodies, autoantigen presentation and ensuing …
well‐established secretion of autoantibodies, autoantigen presentation and ensuing …
B lymphocyte depletion by CD20 monoclonal antibody prevents diabetes in nonobese diabetic mice despite isotype-specific differences in FcγR effector functions
Y Xiu, CP Wong, JD Bouaziz, Y Hamaguchi… - The Journal of …, 2008 - journals.aai.org
NOD mice deficient for B lymphocytes from birth fail to develop autoimmune or type 1
diabetes. To assess whether B cell depletion influences type 1 diabetes in mice with an …
diabetes. To assess whether B cell depletion influences type 1 diabetes in mice with an …