Spinal muscular atrophy (SMA), the leading genetic cause of infant mortality, arises from
survival motor neuron (SMN) protein insufficiency resulting from SMN1 loss. Approved …

Recent unprecedented advances in treatment for spinal muscular atrophy (SMA) enabled
patients to access the first approved disease modifying therapy for the condition. There are …

Harnessing the potential beneficial effects of kinase signalling through the generation of
direct kinase activators remains an underexplored area of drug development,,,–. This also …

Manipulating neural cell behaviors is a critical issue to various therapies for neurological
diseases and damages, where matrix chirality has long been overlooked despite the proven …

Peripheral neuroregeneration research and therapeutic options are expanding
exponentially. With this expansion comes an increasing need to reliably evaluate and …

In older adults, the loss of muscle strength (dynapenia) and the loss of muscle mass
(sarcopenia) are important contributors to the loss of physical function. We sought to …

The ability to measure the passage of electrical current with high spatial and temporal
resolution is vital for applications ranging from inspection of microscopic electronic circuits to …

Skeletal muscle wasting and weakness caused by cancer and its treatments (known as
“cachexia”) drastically impair quality of life and worsen survival outcomes in cancer patients …

Mutations in CHCHD10, a gene coding for a mitochondrial intermembrane space protein,
are associated with Frontotemporal dementia (FTD)-Amyotrophic lateral sclerosis (ALS) …

Motor neurons (MNs) are the neuronal class that is principally affected in amyotrophic lateral
sclerosis (ALS), but it is widely known that individual motor pools do not succumb to …