Location, location, location: how the tissue microenvironment affects inflammation in RA

CD Buckley, C Ospelt, S Gay… - Nature Reviews …, 2021 - nature.com
Current treatments for rheumatoid arthritis (RA) do not work well for a large proportion of
patients, or at all in some individuals, and cannot cure or prevent this disease. One major …

Matrix metalloproteinases and synovial joint pathology

CJ Malemud - Progress in molecular biology and translational …, 2017 - Elsevier
Matrix metalloproteinases (MMPs) are zinc-dependent enzymes. These enzymes play a
critical role in the destruction of articular cartilage in rheumatoid arthritis (RA), osteoarthritis …

Microglia become hypofunctional and release metalloproteases and tau seeds when phagocytosing live neurons with P301S tau aggregates

JH Brelstaff, M Mason, T Katsinelos, WA McEwan… - Science …, 2021 - science.org
The microtubule-associated protein tau aggregates in multiple neurodegenerative diseases,
causing inflammation and changing the inflammatory signature of microglia by unknown …

Non-invasive management of rheumatoid arthritis using hollow microneedles as a tool for transdermal delivery of teriflunomide loaded solid lipid nanoparticles

H Abd-El-Azim, H Abbas, NS El Sayed… - International Journal of …, 2023 - Elsevier
Conventional RA treatments required prolonged therapy courses that have been
accompanied with numerous side effects impairing the patient's quality of life. Therefore …

Biomarkers for diagnosis, monitoring of progression, and treatment responses in ankylosing spondylitis and axial spondyloarthritis

JD Reveille - Clinical rheumatology, 2015 - Springer
With the growing awareness of the impact of chronic back pain and axial spondyloarthritis
and recent breakthroughs in genetics and the development of novel treatments which may …

MMP3 is a reliable marker for disease activity, radiological monitoring, disease outcome predictability, and therapeutic response in rheumatoid arthritis

A Lerner, S Neidhöfer, S Reuter, T Matthias - Best Practice & Research …, 2018 - Elsevier
Matrix metalloproteinase-3 or MMP3 also known as stromelysin-1 is an enzyme that is
actively involved in joint destruction in rheumatoid arthritis (RA) patients. Screening the last …

Biomarker development for axial spondyloarthritis

MA Brown, Z Li, KAL Cao - Nature Reviews Rheumatology, 2020 - nature.com
The term axial spondyloarthritis (axSpA) encompasses a heterogeneous group of diseases
that have variable presentations, extra-articular manifestations and clinical outcomes, and …

The association between the lymphocyte-monocyte ratio and disease activity in rheumatoid arthritis

J Du, S Chen, J Shi, X Zhu, H Ying, Y Zhang… - Clinical …, 2017 - Springer
The lymphocyte-monocyte ratio (LMR) is a systemic inflammatory marker for prediction of
disease development, progress, and survival. Recently, a genome-wide association study …

Engineered artificial articular cartilage made of decellularized extracellular matrix by mechanical and IGF-1 stimulation

M Sani, R Hosseinie, M Latifi, M Shadi… - Biomaterials …, 2022 - Elsevier
Cartilage engineering has the potential to overcome clinical deficiency in joint disorders.
Decellularized extracellular matrix (dECM) has great biocompatibility and bioactivity and can …

[HTML][HTML] Association of matrix metalloproteinase (MMP) gene polymorphisms with knee osteoarthritis: a review of the literature

C Milaras, P Lepetsos, D Dafou, M Potoupnis, E Tsiridis - Cureus, 2021 - ncbi.nlm.nih.gov
Progressive matrix metalloproteinase (MMP)-induced degradation of the extracellular matrix
(ECM) of the articular cartilage is one of the major pathogenic osteoarthritis (OA) events …