Congenital heart disease (CHD) is the most common human birth defect and remains a
leading cause of mortality in childhood. Although advances in clinical management have …

The GeneCards® database of human genes was launched in 1997 and has expanded
since then to encompass gene-centric, disease-centric, and pathway-centric entities and …

Because of remarkable surgical and medical advances over the past several decades, there
are growing numbers of infants and children living with single ventricle congenital heart …

Rationale: Familial recurrence studies provide strong evidence for a genetic component to
the predisposition to sporadic, nonsyndromic Tetralogy of Fallot (TOF), the most common …

Background: Complex molecular programs in specific cell lineages govern human heart
development. Hypoplastic left heart syndrome (HLHS) is the most common and severe …

Hypoplastic left heart syndrome (HLHS) is a complex congenital heart disease characterized
by abnormalities in the left ventricle, associated valves, and ascending aorta. Studies have …

A major goal in the stem cell field is to generate tissues that can be utilized as a universal
tool for in vitro models of development and disease, drug development, or as a resource for …

Congenital heart disease is the most common congenital defect observed in newborns.
Within the spectrum of congenital heart disease are left‐sided obstructive lesions (LSOLs) …

In hypoplastic left heart syndrome (HLHS), the mechanisms leading to left heart hypoplasia
and their associated fetal abnormalities are largely unknown. Current animal models have …

Abstract Background Congenital heart diseases (CHDs) are the most common congenital
anomalies with an estimated prevalence of 8 in 1000 live births. CHDs occur as a result of …