Purinergic signalling, ie, the role of nucleotides as extracellular signalling molecules, was
proposed in 1972. However, this concept was not well accepted until the early 1990's when …

Seven P2X ion channel nucleotide receptor subtypes have been cloned and characterised.
P2X7 receptors (P2X7R) are unusual in that there are extra amino acids in the intracellular …

Ulcerative colitis (UC) and Crohn's disease (CD) are part of Inflammatory Bowel Diseases
(IBD) and have pathophysiological processes such as bowel necrosis and enteric neurons …

The enteric nervous system (ENS) consists of thousands of small ganglia arranged in the
submucosal and myenteric plexuses, which can be negatively affected by Crohn's disease …

Purinergic receptors play an important role in inflammation, and can be activated by ATP
released via pannexin channels and/or connexin hemichannels. The purinergic P2X7 …

Inflammatory bowel disease (IBD) is a serious inflammatory condition of the gastrointestinal
tract. Crohn's disease (CD) and ulcerative colitis (UC) are two of the most common IBD …

The aim of this study was to evaluate the effects of glutamine supplementation or exercise
on gastric emptying and intestinal inflammation in rats with ulcerative colitis (UC). Strength …

The extent of gut inflammation depends largely on the gut barrier's integrity and enteric
neuroimmune interactions. However, the factors and molecular mechanisms that regulate …

Inflammatory bowel diseases (IBDs) are chronic diseases of the gastrointestinal tract that
include ulcerative colitis and Crohn's disease and affect enteric neurons. Research has …

The enteric nervous system (ENS) commands moment‐to‐moment gut functions through
integrative neurocircuitry housed in the gut wall. The functional continuity of ENS networks is …